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Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes
Joint Authors
Bartlett, David B.
Slentz, Cris A.
Connelly, Margery A.
Piner, Lucy W.
Willis, Leslie H.
Bateman, Lori A.
Granville, Esther O.
Bales, Connie W.
Huffman, Kim M.
Kraus, William E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases.
GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins.
This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA in persons at risk for type 2 diabetes.
GlycA, fitness, and body habitus were measured in 169 sedentary adults (45–75 years) with prediabetes randomly assigned to one of four six-month exercise-based lifestyle interventions.
Interventions included exercise prescription based on the amount (energy expenditure (kcal/kg weight/week (KKW)) and intensity (%VO2peak).
The groups were (1) low-amount/moderate-intensity (10KKW/50%) exercise; (2) high-amount/moderate-intensity (16KKW/50%) exercise; (3) high-amount/vigorous-intensity (16KKW/75%) exercise; and (4) a Clinical Lifestyle (combined diet plus low-amount/moderate-intensity exercise) intervention.
Six months of exercise training and/or diet-reduced GlycA (mean Δ: −6.8 ± 29.2 μmol/L; p=0.006) and increased VO2peak (mean Δ: 1.98 ± 2.6 mL/kg/min; p<0.001).
Further, visceral (mean Δ: −21.1 ± 36.6 cm2) and subcutaneous fat (mean Δ: −24.3 ± 41.0 cm2) were reduced, while liver density (mean Δ: +2.3 ± 6.5HU) increased, all p<0.001.
When including individuals in all four interventions, GlycA reductions were associated with reductions in visceral adiposity (p<0.03).
Exercise-based lifestyle interventions reduced GlycA concentrations through mechanisms related to exercise-induced modulations of visceral adiposity.
This trial is registered with Clinical Trial Registration Number NCT00962962.
American Psychological Association (APA)
Bartlett, David B.& Slentz, Cris A.& Connelly, Margery A.& Piner, Lucy W.& Willis, Leslie H.& Bateman, Lori A.…[et al.]. 2017. Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194993
Modern Language Association (MLA)
Bartlett, David B.…[et al.]. Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194993
American Medical Association (AMA)
Bartlett, David B.& Slentz, Cris A.& Connelly, Margery A.& Piner, Lucy W.& Willis, Leslie H.& Bateman, Lori A.…[et al.]. Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194993