The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women
Joint Authors
Li, Dongmei
Meng, Ying
Groth, Susan
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG).
The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG.
An observational study was conducted with 85 African American pregnant women.
Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy.
Seven obesity-risk genetic variants were genotyped.
Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake.
The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines.
A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat P=0.043.
A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG P=0.023.
There was a significant interaction between the KCTD15 polymorphism and dietary fat intake P=0.048.
Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption.
In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG.
Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions.
American Psychological Association (APA)
Meng, Ying& Groth, Susan& Li, Dongmei. 2018. The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195396
Modern Language Association (MLA)
Meng, Ying…[et al.]. The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1195396
American Medical Association (AMA)
Meng, Ying& Groth, Susan& Li, Dongmei. The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195396