The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women
المؤلفون المشاركون
Li, Dongmei
Meng, Ying
Groth, Susan
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG).
The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG.
An observational study was conducted with 85 African American pregnant women.
Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy.
Seven obesity-risk genetic variants were genotyped.
Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake.
The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines.
A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat P=0.043.
A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG P=0.023.
There was a significant interaction between the KCTD15 polymorphism and dietary fat intake P=0.048.
Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption.
In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG.
Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Ying& Groth, Susan& Li, Dongmei. 2018. The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Ying…[et al.]. The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1195396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Ying& Groth, Susan& Li, Dongmei. The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر