Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry
Joint Authors
Uaariyapanichkul, Jaraspong
Suphapeetiporn, Kanya
Chomtho, Sirinuch
Punnahitananda, Santi
Chinjarernpan, Pannee
Suteerojntrakool, Orapa
Shotelersuk, V.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Age, race, and analytic method influence levels of blood amino acids, of which reference intervals are required for the diagnosis and management of inherited metabolic disorders.
Objectives.
To establish age-specific reference intervals for blood amino acids in Thai pediatric population measured by liquid chromatography tandem mass spectrometry (LC-MS/MS).
Methods.
A cross-sectional study of 277 healthy children from birth to 12 years was conducted.
Anthropometric, clinical, and dietary information were recorded.
Dried blood spots on a filtered paper were used for measurement by derivatized LC-MS/MS.
Factors that might affect amino acids such as fasting time and dietary intake were analyzed using quantile regression analysis.
Results.
Levels of thirteen blood amino acids were reported as median and interval from 2.5th–97.5th percentiles.
Compared with those of Caucasian, most blood amino acid levels of Thai children were higher.
Compared with a previous study using HPLC in Thai children, many amino acid levels are different.
Glycine, alanine, leucine/isoleucine, and glutamic acid sharply decreased after birth.
Citrulline, arginine, and methionine stayed low from birth throughout childhood, whereas phenylalanine was at middle level and slightly increased during preadolescence.
Conclusion.
Reference intervals of age-specific blood amino acids using LC-MS/MS were established in the Thai pediatric population.
They diverge from previous studies, substantiating the recommendation that, for the optimal clinical practice, age-specific reference intervals of amino acids should be designated for the particular population and analysis method.
American Psychological Association (APA)
Uaariyapanichkul, Jaraspong& Chomtho, Sirinuch& Suphapeetiporn, Kanya& Shotelersuk, V.& Punnahitananda, Santi& Chinjarernpan, Pannee…[et al.]. 2018. Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1195399
Modern Language Association (MLA)
Uaariyapanichkul, Jaraspong…[et al.]. Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1195399
American Medical Association (AMA)
Uaariyapanichkul, Jaraspong& Chomtho, Sirinuch& Suphapeetiporn, Kanya& Shotelersuk, V.& Punnahitananda, Santi& Chinjarernpan, Pannee…[et al.]. Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1195399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195399