Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry
المؤلفون المشاركون
Uaariyapanichkul, Jaraspong
Suphapeetiporn, Kanya
Chomtho, Sirinuch
Punnahitananda, Santi
Chinjarernpan, Pannee
Suteerojntrakool, Orapa
Shotelersuk, V.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Age, race, and analytic method influence levels of blood amino acids, of which reference intervals are required for the diagnosis and management of inherited metabolic disorders.
Objectives.
To establish age-specific reference intervals for blood amino acids in Thai pediatric population measured by liquid chromatography tandem mass spectrometry (LC-MS/MS).
Methods.
A cross-sectional study of 277 healthy children from birth to 12 years was conducted.
Anthropometric, clinical, and dietary information were recorded.
Dried blood spots on a filtered paper were used for measurement by derivatized LC-MS/MS.
Factors that might affect amino acids such as fasting time and dietary intake were analyzed using quantile regression analysis.
Results.
Levels of thirteen blood amino acids were reported as median and interval from 2.5th–97.5th percentiles.
Compared with those of Caucasian, most blood amino acid levels of Thai children were higher.
Compared with a previous study using HPLC in Thai children, many amino acid levels are different.
Glycine, alanine, leucine/isoleucine, and glutamic acid sharply decreased after birth.
Citrulline, arginine, and methionine stayed low from birth throughout childhood, whereas phenylalanine was at middle level and slightly increased during preadolescence.
Conclusion.
Reference intervals of age-specific blood amino acids using LC-MS/MS were established in the Thai pediatric population.
They diverge from previous studies, substantiating the recommendation that, for the optimal clinical practice, age-specific reference intervals of amino acids should be designated for the particular population and analysis method.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uaariyapanichkul, Jaraspong& Chomtho, Sirinuch& Suphapeetiporn, Kanya& Shotelersuk, V.& Punnahitananda, Santi& Chinjarernpan, Pannee…[et al.]. 2018. Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1195399
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uaariyapanichkul, Jaraspong…[et al.]. Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1195399
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uaariyapanichkul, Jaraspong& Chomtho, Sirinuch& Suphapeetiporn, Kanya& Shotelersuk, V.& Punnahitananda, Santi& Chinjarernpan, Pannee…[et al.]. Age-Related Reference Intervals for Blood Amino Acids in Thai Pediatric Population Measured by Liquid Chromatography Tandem Mass Spectrometry. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1195399
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195399
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر