The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis
Joint Authors
Roehrs, Miguel
Figueiredo, Cassieli Gehlen
Quatrin, Andréia
Somacal, Sabrina
Emanuelli, Tatiana
Barbisan, Fernanda
Teixeira, Cibele F.
Cruz, Ivana B. Mânica da
Conte, Lisiane
Silva, Dariane Trivisiol da
Augusti, Paula Rossini
Maróstica Júnior, Mário Roberto
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties.
The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM).
Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks.
JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis.
Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy.
Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.
American Psychological Association (APA)
Quatrin, Andréia& Conte, Lisiane& Silva, Dariane Trivisiol da& Figueiredo, Cassieli Gehlen& Somacal, Sabrina& Roehrs, Miguel…[et al.]. 2018. The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1195492
Modern Language Association (MLA)
Quatrin, Andréia…[et al.]. The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1195492
American Medical Association (AMA)
Quatrin, Andréia& Conte, Lisiane& Silva, Dariane Trivisiol da& Figueiredo, Cassieli Gehlen& Somacal, Sabrina& Roehrs, Miguel…[et al.]. The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1195492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195492