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The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis
المؤلفون المشاركون
Roehrs, Miguel
Figueiredo, Cassieli Gehlen
Quatrin, Andréia
Somacal, Sabrina
Emanuelli, Tatiana
Barbisan, Fernanda
Teixeira, Cibele F.
Cruz, Ivana B. Mânica da
Conte, Lisiane
Silva, Dariane Trivisiol da
Augusti, Paula Rossini
Maróstica Júnior, Mário Roberto
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties.
The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM).
Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks.
JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis.
Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy.
Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quatrin, Andréia& Conte, Lisiane& Silva, Dariane Trivisiol da& Figueiredo, Cassieli Gehlen& Somacal, Sabrina& Roehrs, Miguel…[et al.]. 2018. The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1195492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quatrin, Andréia…[et al.]. The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1195492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quatrin, Andréia& Conte, Lisiane& Silva, Dariane Trivisiol da& Figueiredo, Cassieli Gehlen& Somacal, Sabrina& Roehrs, Miguel…[et al.]. The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of ThiolDisulfide Redox State through the Upregulation of Glutathione Synthesis. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1195492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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