Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells
Joint Authors
Bajić, Vladan
Živković, Lada
Žukovec Topalović, Dijana
Čabarkapa, Andrea
Spremo-Potparević, Biljana
Borozan, Sunčica
Ciptasari, Ummi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The ability of Agaricus blazei mushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time.
Antigenotoxic effects in human peripheral blood cells against H2O2-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay.
The results showed better antigenotoxic properties of Agaricus blazei on the interventional level, respectively, after treatment.
Agaricus blazei in concentration of 250 μg/mL after treatment was most efficient in regard to its action against DNA damage.
The evaluation of repair kinetics showed decrease in H2O2 induced DNA damage 15 min after the application of A.
blazei, reaching the maximum potency after 30 min.
Analysis of antioxidant properties of Agaricus blazei revealed strong OH• scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak.
In regard to our findings, we can conclude that our preliminary results demonstrated antigenotoxic properties of Agaricus blazei and its strong OH• scavenging ability.
Mechanisms underlying its properties should be further evaluated in in vivo studies.
American Psychological Association (APA)
Živković, Lada& Borozan, Sunčica& Čabarkapa, Andrea& Žukovec Topalović, Dijana& Ciptasari, Ummi& Bajić, Vladan…[et al.]. 2017. Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1196272
Modern Language Association (MLA)
Živković, Lada…[et al.]. Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1196272
American Medical Association (AMA)
Živković, Lada& Borozan, Sunčica& Čabarkapa, Andrea& Žukovec Topalović, Dijana& Ciptasari, Ummi& Bajić, Vladan…[et al.]. Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1196272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196272