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Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells
Joint Authors
López-Alarcón, Camilo
Felipe, Avila
Theoduloz, Cristina
Dorta, Eva
Schmeda-Hirschmann, Guillermo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The prevalence of cytoprotective mechanisms induced by polyphenols such as activation of intracellular antioxidant responses (ICM) and direct free radical scavenging was investigated in native Chilean species of strawberries, raspberries, and currants.
Human gastric epithelial cells were co- and preincubated with polyphenolic-enriched extracts (PEEs) from Chilean raspberries (Rubus geoides), strawberries (Fragaria chiloensis ssp.
chiloensis f.
chiloensis), and currants (Ribes magellanicum) and challenged with peroxyl and hydroxyl radicals.
Cellular protection was determined in terms of cell viability, glyoxalase I and glutathione s-transferases activities, and carboxymethyl lysine (CML) and malondialdehyde levels.
Our results indicate that cytoprotection induced by ICM was the prevalent mechanism for Rubus geoides and F.
chiloensis.
This agreed with increased levels of glyoxalase I and glutathione S-transferase activities in cells preincubated with PEEs.
ORAC index indicated that F.
chiloensis was the most efficient peroxyl radical scavenger.
Moreover, ICM mediated by F.
chiloensis was effective in protecting cells from CML accumulation in contrast to the protective effects induced by free radical scavenging.
Our results indicate that although both polyphenol-mediated mechanisms can exert protective effects, ICM was the most prevalent in AGS cells.
These results suggest a potential use of these native berries as functional food.
American Psychological Association (APA)
Felipe, Avila& Theoduloz, Cristina& López-Alarcón, Camilo& Dorta, Eva& Schmeda-Hirschmann, Guillermo. 2017. Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196737
Modern Language Association (MLA)
Felipe, Avila…[et al.]. Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1196737
American Medical Association (AMA)
Felipe, Avila& Theoduloz, Cristina& López-Alarcón, Camilo& Dorta, Eva& Schmeda-Hirschmann, Guillermo. Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196737