Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients
Joint Authors
Buhmann, Carsten
Poetter-Nerger, Monika
Gulberti, Alessandro
Gerloff, Christian
Hamel, Wolfgang
Hidding, U.
Horn, A.
Koeppen, J. A.
Westphal, M.
Engel, A. K.
Weiss, D.
Moll, C. K. E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The goal of the study was to compare the tolerability and the effects of conventional subthalamic nucleus (STN) and combined subthalamic nucleus and substantia nigra (STN+SNr) high-frequency stimulation in regard to neuropsychiatric symptoms in Parkinson’s disease patients.
In this single center, randomized, double-blind, cross-over clinical trial, twelve patients with advanced Parkinson’s disease (1 female; age: 61.3±7.3 years; disease duration: 12.3±5.4 years; Hoehn and Yahr stage: 2.2±0.39) were included.
Apathy, fatigue, depression, and impulse control disorder were assessed using a comprehensive set of standardized rating scales and questionnaires such as the Lille Apathy Rating Scale (LARS), Modified Fatigue Impact Scale (MFIS), Becks Depression Inventory (BDI-I), Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease Rating Scale (QUIP-RS), and Parkinson’s Disease Questionnaire (PDQ-39).
Three patients that were initially assigned to the STN+SNr stimulation mode withdrew from the study within the first week due to discomfort.
Statistical comparison of data retrieved from patients who completed the study revealed no significant differences between both stimulation conditions in terms of mean scores of scales measuring apathy, fatigue, depression, impulse control disorder, and quality of life.
Individual cases showed an improvement of apathy under combined STN+SNr stimulation.
In general, combined STN+SNr stimulation seems to be safe in terms of neuropsychiatric side effects, although careful patient selection and monitoring in the short-term period after changing stimulation settings are recommended.
American Psychological Association (APA)
Hidding, U.& Gulberti, Alessandro& Horn, A.& Buhmann, Carsten& Hamel, Wolfgang& Koeppen, J. A.…[et al.]. 2017. Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197119
Modern Language Association (MLA)
Hidding, U.…[et al.]. Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients. Parkinson’s Disease No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1197119
American Medical Association (AMA)
Hidding, U.& Gulberti, Alessandro& Horn, A.& Buhmann, Carsten& Hamel, Wolfgang& Koeppen, J. A.…[et al.]. Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197119