Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy
Joint Authors
van der Wal, Selina
Vissers, Kris
Heuvel, Sandra A. S. van den
Smedes, Lotte A.
Radema, Sandra A.
Alfen, Nens van
Steegers, Monique A. H.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Treatment of intractable pain due to chemotherapy induced peripheral neuropathy (CIPN) is a challenge.
Intravenous (iv) lidocaine has shown to be a treatment option for neuropathic pain of different etiologies.
Methods.
Lidocaine (1.5 mg/kg in 10 minutes followed by 1.5 mg/kg/h over 5 hours) was administered in nine patients with CIPN, and analgesic effect was evaluated during infusion and after discharge.
The immediate effect of lidocaine on pressure pain thresholds (PPT) and the extent of the stocking and glove distribution of sensory abnormalities (cold and pinprick) were assessed.
Results.
Lidocaine had a significant direct analgesic effect in 8 out of 9 patients (P=0.01) with a pain intensity difference of >30%.
Pain reduction persisted in 5 patients for an average of 23 days.
Lidocaine did not influence mean PPT, but there was a tendency that the extent of sensory abnormalities decreased after lidocaine.
Conclusion.
Iv lidocaine has direct analgesic effect in CIPN with a moderate long-term effect and seems to influence the area of cold and pinprick perception.
Additional research is needed, using a control group and larger sample sizes to confirm these results.
American Psychological Association (APA)
Heuvel, Sandra A. S. van den& van der Wal, Selina& Smedes, Lotte A.& Radema, Sandra A.& Alfen, Nens van& Vissers, Kris…[et al.]. 2017. Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy. Pain Research and Management،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197513
Modern Language Association (MLA)
Heuvel, Sandra A. S. van den…[et al.]. Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy. Pain Research and Management No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197513
American Medical Association (AMA)
Heuvel, Sandra A. S. van den& van der Wal, Selina& Smedes, Lotte A.& Radema, Sandra A.& Alfen, Nens van& Vissers, Kris…[et al.]. Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197513