Multimodal Approach of Pulmonary Artery Intimal Sarcoma: A Single-Institution Experience
Joint Authors
Morbini, Patrizia
D'Armini, Andrea Maria
Klersy, Catherine
Secondino, S.
Grazioli, V.
Valentino, F.
Pin, M.
Pagani, A.
Sciortino, A.
Callegari, M. G.
Dore, R.
Paulli, M.
Pedrazzoli, Paolo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Pulmonary artery sarcoma (PAS) is a rare tumor, whose therapeutic approach is mainly based on surgery, either pneumonectomy or pulmonary endarterectomy (PEA).
The prognosis reported in published series is very poor, with survival of 1.5 months without any kind of treatment.
Patients and Methods.
From January 2010 to January 2016, 1027 patients were referred to our hospital for symptoms of acute or chronic pulmonary thromboembolic disease.
Twelve patients having a confirmed diagnosis of PAS underwent PEA.
Median age was 64.5 years.
Most patients had a long history of symptoms, having a median time of 7.5 months from onset of symptoms to surgery.
Results.
Following PEA and cardiopulmonary rehabilitation, 10 patients received conventional chemotherapy with doxorubicin and ifosfamide, starting at a median of 42 days from surgery.
Four patients also received radiotherapy.
Four patients have died due to disease progression, while 7 are still alive, with 5 being disease-free at 4–55+ months from diagnosis.
Conclusions.
In patients with PAS, a multimodal approach including PEA, CT, and RT is feasible but it should be evaluated individually, according to the tumor extension and the patient’s clinical condition.
Apart from improving quality of life mainly by reducing or delaying symptoms due to PH, it may improve life expectancy.
American Psychological Association (APA)
Secondino, S.& Grazioli, V.& Valentino, F.& Pin, M.& Pagani, A.& Sciortino, A.…[et al.]. 2017. Multimodal Approach of Pulmonary Artery Intimal Sarcoma: A Single-Institution Experience. Complexity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197745
Modern Language Association (MLA)
Secondino, S.…[et al.]. Multimodal Approach of Pulmonary Artery Intimal Sarcoma: A Single-Institution Experience. Complexity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197745
American Medical Association (AMA)
Secondino, S.& Grazioli, V.& Valentino, F.& Pin, M.& Pagani, A.& Sciortino, A.…[et al.]. Multimodal Approach of Pulmonary Artery Intimal Sarcoma: A Single-Institution Experience. Complexity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197745