Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research
Joint Authors
Ploughman, Michelle
Wadden, Katie P.
Snow, Nicholas J.
Chaves, Arthur R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-16
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system.
Disease progression is variable and unpredictable, warranting the development of biomarkers of disease status.
Transcranial magnetic stimulation (TMS) is a noninvasive method used to study the human motor system, which has shown potential in MS research.
However, few reviews have summarized the use of TMS combined with clinical measures of MS and no work has comprehensively assessed study quality.
This review explored the viability of TMS as a biomarker in studies of MS examining disease severity, cognitive impairment, motor impairment, or fatigue.
Methodological quality and risk of bias were evaluated in studies meeting selection criteria.
After screening 1603 records, 30 were included for review.
All studies showed high risk of bias, attributed largely to issues surrounding sample size justification, experimenter blinding, and failure to account for key potential confounding variables.
Central motor conduction time and motor-evoked potentials were the most commonly used TMS techniques and showed relationships with disease severity, motor impairment, and fatigue.
Short-latency afferent inhibition was the only outcome related to cognitive impairment.
Although there is insufficient evidence for TMS in clinical assessments of MS, this review serves as a template to inform future research.
American Psychological Association (APA)
Snow, Nicholas J.& Wadden, Katie P.& Chaves, Arthur R.& Ploughman, Michelle. 2019. Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research. Neural Plasticity،Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1201522
Modern Language Association (MLA)
Snow, Nicholas J.…[et al.]. Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research. Neural Plasticity No. 2019 (2019), pp.1-22.
https://search.emarefa.net/detail/BIM-1201522
American Medical Association (AMA)
Snow, Nicholas J.& Wadden, Katie P.& Chaves, Arthur R.& Ploughman, Michelle. Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1201522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201522