CD60b: Enriching Neural StemProgenitor Cells from Rat Development into Adulthood
Joint Authors
Pimentel-Coelho, Pedro Moreno
Zaverucha-do-Valle, Camila
Santiago, Marcelo F.
Gubert, Fernanda
Furtado, Michelle
Mortari, Nicoli
Leão, Ana C. M.
Hayashi, Elize A.
Nobrega, Alberto
Mendez-Otero, Rosalia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-15
Country of Publication
Egypt
No. of Pages
16
Abstract EN
CD60b antigens are highly expressed during development in the rat nervous system, while in the adult their expression is restricted to a few regions, including the subventricular zone (SVZ) around the lateral ventricles—a neurogenic niche in the adult brain.
For this reason, we investigated whether the expression of C60b is associated with neural stem/progenitor cells in the SVZ, from development into adulthood.
We performed in vitro and in vivo analyses of CD60b expression at different stages and identified the presence of these antigens in neural stem/progenitor cells.
We also observed that CD60b could be used to purify and enrich a population of neurosphere-forming cells from the developing and adult brain.
We showed that CD60b antigens (mainly corresponding to ganglioside 9-O-acetyl GD3, a well-known molecule expressed during central nervous system development and mainly associated with neuronal migration) are also present in less mature cells and could be used to identify and isolate neural stem/progenitor cells during development and in the adult brain.
A better understanding of molecules associated with neurogenesis may contribute not only to improve the knowledge about the physiology of the mammalian central nervous system, but also to find new treatments for regenerating tissue after disease or brain injury.
American Psychological Association (APA)
Gubert, Fernanda& Zaverucha-do-Valle, Camila& Furtado, Michelle& Pimentel-Coelho, Pedro Moreno& Mortari, Nicoli& Leão, Ana C. M.…[et al.]. 2017. CD60b: Enriching Neural StemProgenitor Cells from Rat Development into Adulthood. Stem Cells International،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1201823
Modern Language Association (MLA)
Gubert, Fernanda…[et al.]. CD60b: Enriching Neural StemProgenitor Cells from Rat Development into Adulthood. Stem Cells International No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1201823
American Medical Association (AMA)
Gubert, Fernanda& Zaverucha-do-Valle, Camila& Furtado, Michelle& Pimentel-Coelho, Pedro Moreno& Mortari, Nicoli& Leão, Ana C. M.…[et al.]. CD60b: Enriching Neural StemProgenitor Cells from Rat Development into Adulthood. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1201823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201823