![](/images/graphics-bg.png)
Peptides from Cauliflower By-Products, Obtained by an Efficient, Ecosustainable, and Semi-Industrial Method, Exert Protective Effects on Endothelial Function
Joint Authors
Capriotti, A. L.
Calabria, D.
Bonvicini, F.
Zenezini Chiozzi, R.
Montone, C. M.
Piovesana, S.
Zangheri, M.
Mirasoli, M.
Simoni, P.
Laganà, A.
Caliceti, Cristiana
Roda, Aldo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The large amount of cauliflower industry waste represents an unexplored source of bioactive compounds.
In this work, peptide hydrolysates from cauliflower leaves were characterized by combined bioanalytical approaches.
Twelve peptide fractions were studied to evaluate unexplored biological activities by effect-based cellular bioassays.
A potent inhibition of intracellular xanthine oxidase activity was observed in human vascular endothelial cells treated with one fraction, with an IC50 = 8.3±0.6 μg/ml.
A different fraction significantly induced the antioxidant enzyme superoxide dismutase 1 and decreased the tumor necrosis factor α-induced VCAM-1 expression, thus leading to a significant improvement in the viability of human vascular endothelial cells.
Shotgun peptidomics and bioinformatics were used to retrieve the most probable bioactive peptide sequences.
Our study shows that peptides from cauliflower waste should be recycled for producing valuable products useful for the prevention of endothelial dysfunction linked to atherogenesis progression.
American Psychological Association (APA)
Caliceti, Cristiana& Capriotti, A. L.& Calabria, D.& Bonvicini, F.& Zenezini Chiozzi, R.& Montone, C. M.…[et al.]. 2019. Peptides from Cauliflower By-Products, Obtained by an Efficient, Ecosustainable, and Semi-Industrial Method, Exert Protective Effects on Endothelial Function. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202013
Modern Language Association (MLA)
Caliceti, Cristiana…[et al.]. Peptides from Cauliflower By-Products, Obtained by an Efficient, Ecosustainable, and Semi-Industrial Method, Exert Protective Effects on Endothelial Function. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1202013
American Medical Association (AMA)
Caliceti, Cristiana& Capriotti, A. L.& Calabria, D.& Bonvicini, F.& Zenezini Chiozzi, R.& Montone, C. M.…[et al.]. Peptides from Cauliflower By-Products, Obtained by an Efficient, Ecosustainable, and Semi-Industrial Method, Exert Protective Effects on Endothelial Function. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202013