Literature-Based Enrichment Insights into Redox Control of Vascular Biology
Joint Authors
Bajic, Vladimir
Isenovic, Esma R.
Essack, Magbubah
Salhi, Adil
Stanimirovic, Julijana
Tifratene, Faroug
Bin Raies, Arwa
Hungler, Arnaud
Uludag, Mahmut
Van Neste, Christophe
Trpkovic, Andreja
Bajic, Vladan P.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
In cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles.
ROS overproduction leads to cellular oxidative stress.
This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers.
In this study, we focus on the redox effects related to vascular systems in mammals.
To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature.
The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems.
It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associations of pairs of such enriched concepts, where associations themselves are statistically enriched.
For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc.
that allow for insights about different aspects of redox effects and control of processes related to the vascular system.
Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc.
DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic.
American Psychological Association (APA)
Essack, Magbubah& Salhi, Adil& Stanimirovic, Julijana& Tifratene, Faroug& Bin Raies, Arwa& Hungler, Arnaud…[et al.]. 2019. Literature-Based Enrichment Insights into Redox Control of Vascular Biology. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1202372
Modern Language Association (MLA)
Essack, Magbubah…[et al.]. Literature-Based Enrichment Insights into Redox Control of Vascular Biology. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1202372
American Medical Association (AMA)
Essack, Magbubah& Salhi, Adil& Stanimirovic, Julijana& Tifratene, Faroug& Bin Raies, Arwa& Hungler, Arnaud…[et al.]. Literature-Based Enrichment Insights into Redox Control of Vascular Biology. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1202372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202372