Spontaneous Slowing and Regressing of Tumor Growth in ChildhoodAdolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time
Joint Authors
Kasahara, Toshihiko
Kudo, Takumi
Ito, Mitsuru
Nishihara, Eijun
Miyauchi, Akira
Kihara, Minoru
Ito, Yasuhiro
Miya, Akihiro
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease.
The tumor growth of young patients’ PTCs might show spontaneous slowing postoperatively.
We compared young PTC patients’ postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT).
Methods.
Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998–2016 had biochemically persistent disease postoperatively.
We calculated their Tg-DTs and estimated their preoperative TV-DTs with the tumor size and the patient’s age at surgery, presuming that a single cancer cell was present at the patient’s birth.
Results.
Twelve patients had positive Tg-DTs ranging from 2.0 to 147 years, and the remaining two had negative Tg-DTs, indicating slow growth or even regression.
The hTV-DTs were 0.3–0.6 years (median 0.5 years), which were significantly shorter than the Tg-DTs (p<0.001), indicating much faster growth preoperatively.
The analyses of the nine patients without radioactive iodine administration (RAI) gave similar results (p<0.01).
Conclusions.
Irrespective of RAI, the patients’ postoperative Tg-DTs were significantly longer than their preoperative hTV-DTs and were negative values in two patients, indicating that the growth of these young patients’ PTCs had spontaneously slowed or even regressed postoperatively.
American Psychological Association (APA)
Kasahara, Toshihiko& Miyauchi, Akira& Kudo, Takumi& Nishihara, Eijun& Ito, Mitsuru& Ito, Yasuhiro…[et al.]. 2018. Spontaneous Slowing and Regressing of Tumor Growth in ChildhoodAdolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time. Journal of Thyroid Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203089
Modern Language Association (MLA)
Kasahara, Toshihiko…[et al.]. Spontaneous Slowing and Regressing of Tumor Growth in ChildhoodAdolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time. Journal of Thyroid Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203089
American Medical Association (AMA)
Kasahara, Toshihiko& Miyauchi, Akira& Kudo, Takumi& Nishihara, Eijun& Ito, Mitsuru& Ito, Yasuhiro…[et al.]. Spontaneous Slowing and Regressing of Tumor Growth in ChildhoodAdolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time. Journal of Thyroid Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203089