Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association
Joint Authors
Cabrera, Mayela
Cano, Climaco
Salazar, Juan
Rojas, Milagros
Estrella, Viviana
Ordoñez, María
Hernández, Juan Diego
Arias, Víctor
Rojas, Joselyn
Bermúdez, Valmore
Áñez, Roberto
Chacín, Maricarmen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Subclinical hypothyroidism (ScH) is an endocrine alteration that is related to cardiovascular risk factors, including those categorized as components of the Metabolic Syndrome (MS).
However, findings in prior reports regarding an association between these alterations are inconsistent.
The purpose of this study was to determine the relationship between both entities in adult subjects from Maracaibo City, Venezuela.
Materials and Methods.
The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multistage sampling.
In this substudy, 391 individuals of both genders were selected and TSH, free T3, and free T4 tests were performed as well as a complete lipid profile, fasting glycaemia, and insulin blood values.
ScH was defined according to the National Health and Nutrition Examination Survey (NHANES) criteria: high TSH (≥4.12mUI/L) and normal free T4 (0.9-1,9 ng/dL) in subjects without personal history of thyroid disease.
MS components were defined according to IDF/AHA/NHLBI/WHF/IAS/IASO-2009 criteria.
A multiple logistic regression analysis was used to assess the relationship between MS components and ScH diagnosis.
Results.
Of the evaluated population, 10.5% (n=41) was diagnosed with ScH, with a higher prevalence in women (female: 13.6% versus male: 7.7%; χ2=3.56, p=0.05).
Likewise, 56.1% (n=23) of the subjects with ScH were diagnosed with MS (χ2=4.85; p=0.03), being hyperglycemia the main associated criterion (χ2=11.7; p=0.001).
In multivariable analysis, it was observed that the relationship was exclusive with the presence of type 2 diabetes mellitus (T2DM) OR: 3.22 (1.14-9.14); p=0.03.
Conclusion.
The relationship between ScH and MS in our population is dependent on the presence of hyperglycemia, specifically T2DM diagnosis, findings that vary from those previously reported in Latin American subjects.
American Psychological Association (APA)
Bermúdez, Valmore& Salazar, Juan& Áñez, Roberto& Rojas, Milagros& Estrella, Viviana& Ordoñez, María…[et al.]. 2018. Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association. Journal of Thyroid Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203094
Modern Language Association (MLA)
Bermúdez, Valmore…[et al.]. Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association. Journal of Thyroid Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203094
American Medical Association (AMA)
Bermúdez, Valmore& Salazar, Juan& Áñez, Roberto& Rojas, Milagros& Estrella, Viviana& Ordoñez, María…[et al.]. Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association. Journal of Thyroid Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203094