Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation
Joint Authors
Racine, Normand
Iannino, Nadia
Nasri, Amine
Räkel, Agnès
Ducharme, Anique
Lachance, Kim
Tremblay-Gravel, Maxime
Fortier, Annik
White, Michel
de Denus, Simon
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Recent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM).
We investigated the secular trends of the risk of PTDM at 1 year and 3 years after transplantation over 30 years and explored its effect on major outcomes.
Methods.
Three hundred and three nondiabetic patients were followed for a minimum of 36 months, after a first cardiac transplantation performed between 1983 and 2011.
Based on the year of their transplantation, the patients were divided into 3 eras: (1983-1992 [era 1], 1993-2002 [era 2], and 2003-2011 [era 3]).
Results.
In eras 1, 2, and 3, the proportions of patients with PTDM at 1 versus 3 years were 23% versus 39%, 21% versus 26%, and 33% versus 38%, respectively.
Independent risk factors predicting PTDM at one year were recipient’s age, duration of cold ischemic time, treatment with furosemide, and tacrolimus.
There was a trend for overall survival being worse for patients with PTDM in comparison to patients without PTDM (p = 0.08).
Patients with PTDM exhibited a significantly higher rate of renal failure over a median follow-up of 10 years (p = 0.03).
Conclusion.
The development of PTDM following cardiac transplantation approaches 40% at 3 years and has not significantly changed over thirty years.
The presence of PTDM is weakly associated with an increased mortality and is significantly associated with a worsening in renal function long-term following cardiac transplantation.
American Psychological Association (APA)
Iannino, Nadia& Nasri, Amine& Räkel, Agnès& Ducharme, Anique& Lachance, Kim& Racine, Normand…[et al.]. 2018. Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation. Journal of Transplantation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1203163
Modern Language Association (MLA)
Iannino, Nadia…[et al.]. Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation. Journal of Transplantation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1203163
American Medical Association (AMA)
Iannino, Nadia& Nasri, Amine& Räkel, Agnès& Ducharme, Anique& Lachance, Kim& Racine, Normand…[et al.]. Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation. Journal of Transplantation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1203163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203163