Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome
Joint Authors
Abdalqader, Manal Madany
Hussein, Shatha Sami
Source
Obstetrics and Gynecology International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers.
Study Design.
A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women diagnosed as PCOS, 22 women with BMI ≥ 25 kg/m2 and 22 women with BMI < 25 kg/m2, and another 43 women without PCOS, 22 women with BMI ≥ 25 kg/m2 and 21 women with BMI < 25 kg/m2.
Hormonal, metabolic profiles, and hirsutism scores, as well as serum kisspeptin level, were assessed by using Human Kisspeptin 1(KISS-1) ELISA Kit.
The blood samples between days 2 and 5 of menstrual cycle were drawn by an disposable sterile syringe and collected in EDTA containing tubes (as anticoagulant), and the hormonal profile was measured using a biotech ELISA reader.
Result.
Serum level of kisspeptin was significantly higher in PCOS compared to control (322.4 vs.
235.3 ng/L, respectively).
There was no significant difference in age, BMI, and parity between control and PCOS; the frequency of hirsutism, acne, elevated LH, and increased free testosterone (fTT) were significantly higher in PCOS compared to control.
Kisspeptin shows a direct significant correlation with hirsutism and fTT (r = 0.648, 0.238, respectively).
In ROC analysis, kisspeptin had AUC (95% CI) = 0.874 (0.785–0.935) for predicting PCOS.
Conclusion.
Kisspeptin levels might be used as a marker for hyperandrogenemia in polycystic ovarian syndrome.
American Psychological Association (APA)
Abdalqader, Manal Madany& Hussein, Shatha Sami. 2020. Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome. Obstetrics and Gynecology International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1203342
Modern Language Association (MLA)
Abdalqader, Manal Madany& Hussein, Shatha Sami. Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome. Obstetrics and Gynecology International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1203342
American Medical Association (AMA)
Abdalqader, Manal Madany& Hussein, Shatha Sami. Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome. Obstetrics and Gynecology International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1203342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203342