Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value
Joint Authors
Colak, Ertugrul
Uzuner, Nevzat
Baş, Demet Funda
Sadeghi-Hokmabadi, Elyar
Taheraghdam, Aliakbar
Hashemilar, Mazyar
Farhoudi, Mehdi
Savadi Oskouei, Daryoush
Yazdchi, Mohammad
Özdemir, Atilla Özcan
Mirnour, Reshad
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT).
Methods.
This multicenter research involved 403 patients from January 2009 to March 2015.
Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2 and (2) low GFR group with GFR < 45 mL/min/1.73 m2.
Outcome measurements were poor outcome (mRS 3–6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24–36 hours.
Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs).
Results.
Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09–1.30, p<0.001) and mortality (OR 1.18, 95% CI 1.06–1.32, p=0.002).
In multivariate regression, adjusted for all variables with p value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01–4.56, p=0.045).
Conclusion.
In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2.
American Psychological Association (APA)
Sadeghi-Hokmabadi, Elyar& Baş, Demet Funda& Farhoudi, Mehdi& Taheraghdam, Aliakbar& Savadi Oskouei, Daryoush& Yazdchi, Mohammad…[et al.]. 2017. Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value. Stroke Research and Treatment،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1203529
Modern Language Association (MLA)
Sadeghi-Hokmabadi, Elyar…[et al.]. Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value. Stroke Research and Treatment No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1203529
American Medical Association (AMA)
Sadeghi-Hokmabadi, Elyar& Baş, Demet Funda& Farhoudi, Mehdi& Taheraghdam, Aliakbar& Savadi Oskouei, Daryoush& Yazdchi, Mohammad…[et al.]. Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value. Stroke Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1203529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203529