Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region
Joint Authors
Focà, Alfredo
Galati, Luisa
Mazzitelli, Maria
Loria, Maria Teresa
Peronace, Cinzia
Catanzariti, Tatiana
Settembre, Pio
Dodaro, Gessica
Torti, Carlo
Giancotti, Aida
Liberto, Maria Carla
Barreca, Giorgio S.
Strazzulla, Alessio
Lamberti, Angelo G.
Quirino, Angela
Matera, Giovanni
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We aim to investigate some of the pathogenetic mediators of the human echinococcosis and to obtain updated epidemiological findings on cases of echinococcosis in Calabria, Southern Italy.
Echinococcosis diagnosis was based on imaging, serological investigations, and molecular assay.
Indeed, real-time PCR indicated the presence of G2/G3 genotypes of Echinococcus granulosus complex.
Regarding pathogenesis, a relevant novel tool of immune depression should be deemed the reduced level of serum MCP-1.
Also, we found a previously unreported VEGF, possibly associated with neovascularization requested by the parasite cyst metabolism.
Cytokine profiles suggest a bias of the immunity toward Th2 and Treg responses.
Nitric oxide levels exhibited a significant decrease one week after therapy versus basal level measured before surgery and/or chemotherapy.
An increase of serum total IgE class and IgG4 subclass was found in Echinococcus-positive patients versus controls.
Our data demonstrated an endemic spreading, at least in the province of Catanzaro and neighboring Calabria territories, for such parasitosis with the novel issue of the number of female overcoming male cases.
In conclusion, the novel findings of this study were the increased VEGF and the reduced serum MCP-1 in the studied cases, as well as the number of Echinococcus-infected females overcoming the infected males.
American Psychological Association (APA)
Matera, Giovanni& Loria, Maria Teresa& Peronace, Cinzia& Catanzariti, Tatiana& Settembre, Pio& Giancotti, Aida…[et al.]. 2018. Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1203749
Modern Language Association (MLA)
Matera, Giovanni…[et al.]. Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1203749
American Medical Association (AMA)
Matera, Giovanni& Loria, Maria Teresa& Peronace, Cinzia& Catanzariti, Tatiana& Settembre, Pio& Giancotti, Aida…[et al.]. Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1203749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203749