Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
Joint Authors
Schini-Kerth, Valérie B.
Medeiros, Isac Almeida de
de Azevedo, Fátima de L. A. A.
da Silva, Tays A. F.
Almeida, Arthur José Pontes Oliveira de
de Almeida Rezende, Mathania Silva
Dantas, Sabine Helena
de Lima Silva, Sonaly
de Oliveira, Júlio César Pinheiro Lúcio
Alves, Rayanne Maira Felix Ribeiro
de Menezes, Geovânia Maria Sales
dos Santos, Pablo Ferreira
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-09
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase in the prevalence of age-related chronic diseases, highlighting cardiovascular diseases (CVDs), such as hypertension, atherosclerosis, and heart failure.
Aging is the main risk factor for these diseases.
Such susceptibility to disease is explained, at least in part, by the increase of oxidative stress, in which it damages cellular components such as proteins, DNA, and lipids.
In addition, the chronic inflammatory process in aging “inflammaging” also contributes to cell damage, creating a stressful environment which drives to the development of CVDs.
Taken together, it is possible to identify the molecular connection between oxidative stress and the inflammatory process, especially by the crosstalk between the transcription factors Nrf-2 and NF-κB which are mediated by redox signalling and are involved in aging.
Therapies that control this process are key targets in the prevention/combat of age-related CVDs.
In this review, we show the basics of inflammation and oxidative stress, including the crosstalk between them, and the implications on age-related CVDs.
American Psychological Association (APA)
Almeida, Arthur José Pontes Oliveira de& de Almeida Rezende, Mathania Silva& Dantas, Sabine Helena& de Lima Silva, Sonaly& de Oliveira, Júlio César Pinheiro Lúcio& de Azevedo, Fátima de L. A. A.…[et al.]. 2020. Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1203857
Modern Language Association (MLA)
Almeida, Arthur José Pontes Oliveira de…[et al.]. Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1203857
American Medical Association (AMA)
Almeida, Arthur José Pontes Oliveira de& de Almeida Rezende, Mathania Silva& Dantas, Sabine Helena& de Lima Silva, Sonaly& de Oliveira, Júlio César Pinheiro Lúcio& de Azevedo, Fátima de L. A. A.…[et al.]. Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1203857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203857