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Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response
Joint Authors
Fadriquela, Ailyn
Sajo, Ma Easter Joy
Bajgai, Johny
Kim, Dong-Heui
Kim, Cheol-Su
Kim, Soo-Ki
Lee, Kyu-Jae
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field.
This study is aimed at exploring StAEW as a potential wound care agent and its mechanism.
StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of hairless mice for seven days.
Wound morphological and histological features and immune-redox markers were compared with saline- (Sal-) and alcohol- (Alc-) treated groups.
Results showed that the StAEW group showed a significantly higher wound healing percentage than the Sal group on days 2, 4, 5, and 6 and the Alc group on day 4.
The StAEW group also showed earlier mediation on proinflammatory cytokines such as tumor necrosis factor-α, interleukin- (IL-) 6, IL-1β, and keratinocyte chemoattractant.
In addition, basic fibroblast growth factor and platelet-derived growth factor were found to be significantly changed in favor of the fibroblast synthesis and angiogenesis.
In line, the StAEW group showed a controlled amount of ROS and significantly decreased compared to the Alc group.
The StAEW group also favored oxidative stress balance through antioxidant responses.
Additionally, matrix metalloproteinases (MMP) 9 and MMP1 were also modulated for keratinocyte and cell migration.
Taken together, this study has proven the wound healing effect of StAEW and its earlier mediation through oxidative and inflammatory responses.
American Psychological Association (APA)
Fadriquela, Ailyn& Sajo, Ma Easter Joy& Bajgai, Johny& Kim, Dong-Heui& Kim, Cheol-Su& Kim, Soo-Ki…[et al.]. 2020. Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203956
Modern Language Association (MLA)
Fadriquela, Ailyn…[et al.]. Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203956
American Medical Association (AMA)
Fadriquela, Ailyn& Sajo, Ma Easter Joy& Bajgai, Johny& Kim, Dong-Heui& Kim, Cheol-Su& Kim, Soo-Ki…[et al.]. Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203956