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Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide
Joint Authors
Cury-Boaventura, Maria Fernanda
Vieira, Rodolfo P.
Oliveira-Junior, Manoel Carneiro
Saraiva-Romanholo, Beatriz Mangueira
Sierra, Ana P. R.
Oliveira, Rodrigo A.
Pesquero, João B.
Benetti, Marino
Ghorayeb, Nabil
Kiss, Maria Augusta Peduti Dal Molin
Almeida, Francine Maria
Felix, Soraia Nogueira
Genaro, Isabella Santos
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The endurance exercise is capable of inducing skeletal muscle, heart, and respiratory fatigue, evidenced by morphofunctional cardiac changes, release of myocardial injury biomarkers, and reduction of maximal voluntary ventilation and oxygen consumption (VO2) at peak exercise.
Purpose.
The aim of this study was to investigate whether marathoners present cardiac fatigue after marathon and whether it correlates with pulmonary levels of exhaled nitric oxide (eNO) and pulmonary inflammation.
Methods.
31 male marathoners, age 39±9 years, were evaluated by cardiopulmonary exercise test three weeks before and between three and 15 days after a marathon; eNO analysis and spirometry were evaluated before, immediately after, and 24 and 72 hours after the marathon, and sputum cellularity and cytokine level were assessed before and after the marathon.
Results.
Marathon induced an increase in the percentage of macrophages, neutrophils (from 0.65% to 4.28% and 6.79% to 14.11%, respectively), and epithelial cells and a decrease in cytokines in induced sputum, followed by an increase in eNO concentration (20±11 to 35±19 ppb), which presented a significant reduction 24 and 72 hours after marathon (9±12 e 12±9 ppb, p<0.05).
We observed a decrease in the spirometry parameters in all time points assessed after the marathon (p<0.05) as well as in cardiopulmonary capacity, evidenced by a reduction in VO2 and ventilation peaks (57±6 to 55±6 mL·min-1·Kg-1 and 134±19 to 132±18 Lpm, respectively, p<0.05).
Finally, we observed a negative correlation between the decrease in forced expiratory volume and decrease in eNO 24 and 72 hours after marathon (r=−0.4, p=0.05).
Conclusion.
Reduction in eNO bioavailability after marathon prevents the reduction in cardiopulmonary capacity induced by acute inflammatory pattern after marathon.
American Psychological Association (APA)
Sierra, Ana P. R.& Oliveira-Junior, Manoel Carneiro& Almeida, Francine Maria& Benetti, Marino& Oliveira, Rodrigo A.& Felix, Soraia Nogueira…[et al.]. 2019. Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1203976
Modern Language Association (MLA)
Sierra, Ana P. R.…[et al.]. Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1203976
American Medical Association (AMA)
Sierra, Ana P. R.& Oliveira-Junior, Manoel Carneiro& Almeida, Francine Maria& Benetti, Marino& Oliveira, Rodrigo A.& Felix, Soraia Nogueira…[et al.]. Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1203976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203976