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Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation
Joint Authors
Chae, Min Suk
Kim, Youngchan
Chung, Hyun Sik
Park, Chul Soo
Lee, Jaemin
Choi, Jong Ho
Hong, Sang Hyun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Previous studies have shown that a higher serum interleukin- (IL-) 6 level is associated with a higher risk of acute kidney injury (AKI) development after major nontransplant surgery.
Our study investigated the potential association of preoperative serum cytokine profiles with new AKI development in patients who underwent living donor liver transplantation (LDLT).
Methods.
Serum levels of cytokines IL-2, IL-6, IL-10, IL-12, and IL-17, interferon-γ, and tumor necrosis factor- (TNF-) α were measured in 226 LDLT recipients preoperatively and analyzed retrospectively.
Recipients with a preoperative functional impairment of the kidney were excluded.
AKI was defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria.
Results.
In a univariate regression model, IL-6, IL-17, and TNF-α levels showed an association with AKI development after LDLT.
Multivariate analysis showed an independent association of the preoperative serum IL-6 level with AKI development after LDLT and a significant relationship between higher serum IL-6 levels and a greater likelihood of developing AKI.
Serum IL-6 levels were higher in patients with stage 3 AKI than in patients who did not develop AKI.
Conclusions.
Our results support the need for further investigations of IL-6 as a predictor of AKI development in patients undergoing LDLT.
American Psychological Association (APA)
Chae, Min Suk& Kim, Youngchan& Chung, Hyun Sik& Park, Chul Soo& Lee, Jaemin& Choi, Jong Ho…[et al.]. 2018. Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1204296
Modern Language Association (MLA)
Chae, Min Suk…[et al.]. Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation. Mediators of Inflammation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1204296
American Medical Association (AMA)
Chae, Min Suk& Kim, Youngchan& Chung, Hyun Sik& Park, Chul Soo& Lee, Jaemin& Choi, Jong Ho…[et al.]. Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1204296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204296