Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus
Joint Authors
Ou, Yangping
Geng, Yi
Feng, Yang
Huang, Xiaoli
Wang, Kaiyu
Chen, Defang
Yang, Shiyong
Tang, Hong
Xiong, Guanqing
Li, Liangyu
Yang, Yucen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Most species of the genus Elizabethkingia are pathogenic to humans and animals, most commonly causing meningitis.
However, our understanding of the pathogenic mechanisms involved is poor and there have been few pathological studies of Elizabethkingia spp.
in animals.
To understand the host injury induced by Elizabethkingia spp., we established a model of E.
miricola infection in the black-spotted frog (Pelophylax nigromaculatus).
The systematic pathology in and oxidative damage in the infection model were investigated.
Our results show that recently isolated E.
miricola is a bacterium that mainly parasitizes the host brain and that neurogenic organs are the predominant sites of damage.
Infection mainly manifested as severe brain abscesses, meningoencephalitis, necrotic spondylitis, and necrotic retinitis.
The liver, spleen, kidney, gastrointestinal tract, and lung were also affected to varying degrees, with bacterial necrotic inflammation.
P.
nigromaculatus also suffered enormous damage to its oxidative system during E.
miricola infection, which may have further aggravated its disease state.
Our results provide a preliminary reference for the study and treatment of Elizabethkingia spp.-induced neurological diseases in animals.
American Psychological Association (APA)
Huang, Xiaoli& Feng, Yang& Tang, Hong& Xiong, Guanqing& Li, Liangyu& Yang, Yucen…[et al.]. 2019. Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204604
Modern Language Association (MLA)
Huang, Xiaoli…[et al.]. Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204604
American Medical Association (AMA)
Huang, Xiaoli& Feng, Yang& Tang, Hong& Xiong, Guanqing& Li, Liangyu& Yang, Yucen…[et al.]. Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204604