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Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2ROS Pathway
Joint Authors
Lu, Guotao
Li, Weiqin
Xia, Qing
Gong, Weijuan
Xiao, Weiming
Chen, Weiwei
Huang, Wei
Yuan, Chenchen
Lu, Yingying
Zhu, Qingtian
Ma, Xiaojie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Danshen (Salvia miltiorrhiza Bunge) and its main active component Tanshinone IIA (TSA) are clinically used in China.
However, the effects of TSA on acute pancreatitis (AP) and its potential mechanism have not been investigated.
In this study, our objective was to investigate the protective effects of TSA against AP via three classic mouse models.
Methods.
Mouse models of AP were established by caerulein, sodium taurocholate, and L-arginine, separately.
Pancreatic and pulmonary histopathological characteristics and serum amylase and lipase levels were evaluated, and changes in oxidative stress injury and the ultrastructure of acinar cells were observed.
The reactive oxygen species (ROS) inhibitor N-Acetylcysteine (NAC) and nuclear factor erythroid 2-related factor 2 (Nrf2) knockout mice were applied to clarify the protective mechanism of the drug.
Results.
In the caerulein-induced AP model, TSA administration reduced serum amylase and lipase levels and ameliorated the histopathological manifestations of AP in pancreatic tissue.
Additionally, TSA appreciably decreased ROS release, protected the structures of mitochondria and the endoplasmic reticulum, and increased the protein expression of Nrf2 and heme oxygenase 1 of pancreatic tissue.
In addition, the protective effects of TSA against AP were counteracted by blocking the oxidative stress (NAC administration and Nrf2 knockout in mice).
Furthermore, we found that TSA protects pancreatic tissue from damage and pancreatitis-associated lung injury in two additional mouse models induced by sodium taurocholate and by L-arginine.
Conclusion.
Our data confirmed the protective effects of TSA against AP in mice by inhibiting oxidative stress via the Nrf2/ROS pathway.
American Psychological Association (APA)
Chen, Weiwei& Yuan, Chenchen& Lu, Yingying& Zhu, Qingtian& Ma, Xiaojie& Xiao, Weiming…[et al.]. 2020. Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2ROS Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204830
Modern Language Association (MLA)
Chen, Weiwei…[et al.]. Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2ROS Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204830
American Medical Association (AMA)
Chen, Weiwei& Yuan, Chenchen& Lu, Yingying& Zhu, Qingtian& Ma, Xiaojie& Xiao, Weiming…[et al.]. Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2ROS Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204830