Factors Associated with Mortality among Patients on TB Treatment in the Southern Region of Zimbabwe, 2013
Joint Authors
Siziba, Nicholas
Sandy, Charles
Takarinda, Kudakwashe C.
Masuka, Nyasha
Hazangwe, Patrick
Choto, Regis C.
Mutasa-Apollo, Tsitsi
Nkomo, Brilliant
Sibanda, Edwin
Mugurungi, Owen
Harries, Anthony D.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
In 2013, the tuberculosis (TB) mortality rate was highest in southern Zimbabwe at 16%.
We therefore sought to determine factors associated with mortality among registered TB patients in this region.
Methodology.
This was a retrospective record review of registered patients receiving anti-TB treatment in 2013.
Results.
Of 1,971 registered TB patients, 1,653 (84%) were new cases compared with 314 (16%) retreatment cases.
There were 1,538 (78%) TB/human immunodeficiency virus (HIV) coinfected patients, of whom 1,399 (91%) were on antiretroviral therapy (ART) with median pre-ART CD4 count of 133 cells/uL (IQR, 46–282).
Overall, 428 (22%) TB patients died.
Factors associated with increased mortality included being ≥65 years old [adjusted relative risk (ARR) = 2.48 (95% CI 1.35–4.55)], a retreatment TB case [ARR = 1.34 (95% CI, 1.10–1.63)], and being HIV-positive [ARR = 1.87 (95% CI, 1.44–2.42)] whilst ART initiation was protective [ARR = 0.25 (95% CI, 0.22–0.29)].
Cumulative mortality rates were 10%, 14%, and 21% at one, two, and six months, respectively, after starting TB treatment.
Conclusion.
There was high mortality especially in the first two months of anti-TB treatment, with risk factors being recurrent TB and being HIV-infected, despite a high uptake of ART.
American Psychological Association (APA)
Takarinda, Kudakwashe C.& Sandy, Charles& Masuka, Nyasha& Hazangwe, Patrick& Choto, Regis C.& Mutasa-Apollo, Tsitsi…[et al.]. 2017. Factors Associated with Mortality among Patients on TB Treatment in the Southern Region of Zimbabwe, 2013. Tuberculosis Research and Treatment،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1205253
Modern Language Association (MLA)
Takarinda, Kudakwashe C.…[et al.]. Factors Associated with Mortality among Patients on TB Treatment in the Southern Region of Zimbabwe, 2013. Tuberculosis Research and Treatment No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1205253
American Medical Association (AMA)
Takarinda, Kudakwashe C.& Sandy, Charles& Masuka, Nyasha& Hazangwe, Patrick& Choto, Regis C.& Mutasa-Apollo, Tsitsi…[et al.]. Factors Associated with Mortality among Patients on TB Treatment in the Southern Region of Zimbabwe, 2013. Tuberculosis Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1205253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205253