Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model
Joint Authors
Xiao, Shune
Wei, Zairong
Deng, Chengliang
Wang, Dali
Liu, Zhiyuan
Tao, Kerong
Li, Hai
Jin, Wenhu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-30
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Pressure injury (PI) affects quality of life and results in economic and social burdens.
Local transplantation of human adipose-derived stem cells (ASCs) is considered an effective treatment.
However, ASC suspension alone is vulnerable to the immune system and results in a shortened cell survival.
There is increasing evidence of a synergistic effect of platelet-rich plasma (PRP) combined with ASCs on wound healing.
This study investigated the effectiveness, synergy, and mechanism of wound healing following local injection of PRP combined with ASCs in a rodent PI model.
PRP or ASCs alone were the control intervention.
Wound healing, inflammatory infiltration, collagen deposition, angiogenesis, neurogenesis, and cell homing were investigated.
PI healing was promoted by the synergistic effects of PRP combined with ASCs.
The combination was more effective than ASCs alone for modulating inflammation, increasing collagen deposition, angiogenesis, neurogenesis, and the persistence of the injected ASCs.
These data provide a theoretical foundation for the clinical administration of ASCs combined with PRP in PI healing and skin regeneration.
American Psychological Association (APA)
Liu, Zhiyuan& Xiao, Shune& Tao, Kerong& Li, Hai& Jin, Wenhu& Wei, Zairong…[et al.]. 2019. Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model. Stem Cells International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1208594
Modern Language Association (MLA)
Liu, Zhiyuan…[et al.]. Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model. Stem Cells International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1208594
American Medical Association (AMA)
Liu, Zhiyuan& Xiao, Shune& Tao, Kerong& Li, Hai& Jin, Wenhu& Wei, Zairong…[et al.]. Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1208594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208594