ACT-SVM: Prediction of Protein-Protein Interactions Based on Support Vector Basis Model
Joint Authors
Cao, Yi
Bao, Wenzheng
Chen, Yuehui
Ma, Wenzheng
Yang, Bin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The interactions between proteins play important roles in several organisms, and such issue can be involved in almost all activities in the cell.
The research of protein-protein interactions (PPIs) can make a huge contribution to the prevention and treatment of diseases.
Currently, many prediction methods based on machine learning have been proposed to predict PPIs.
In this article, we propose a novel method ACT-SVM that can effectively predict PPIs.
The ACT-SVM model maps protein sequences to digital features, performs feature extraction twice on the protein sequence to obtain vector A and descriptor CT, and combines them into a vector.
Then, the feature vectors of the protein pair are merged as the input of the support vector machine (SVM) classifier.
We utilize nonredundant H.
pylori and human dataset to verify the prediction performance of our method.
Finally, the proposed method has a prediction accuracy of 0.727897 for H.
pylori data and a prediction accuracy of 0.838799 for human dataset.
The results demonstrate that this method can be called a stable and reliable prediction model of PPIs.
American Psychological Association (APA)
Ma, Wenzheng& Cao, Yi& Bao, Wenzheng& Yang, Bin& Chen, Yuehui. 2020. ACT-SVM: Prediction of Protein-Protein Interactions Based on Support Vector Basis Model. Scientific Programming،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1209269
Modern Language Association (MLA)
Ma, Wenzheng…[et al.]. ACT-SVM: Prediction of Protein-Protein Interactions Based on Support Vector Basis Model. Scientific Programming No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1209269
American Medical Association (AMA)
Ma, Wenzheng& Cao, Yi& Bao, Wenzheng& Yang, Bin& Chen, Yuehui. ACT-SVM: Prediction of Protein-Protein Interactions Based on Support Vector Basis Model. Scientific Programming. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1209269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209269