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Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes
Joint Authors
Drela, Katarzyna
Nowakowski, Adam
Lukomska, Barbara
Stanaszek, Luiza
Kuczynska, Zuzanna
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Mesenchymal stem cells (MSCs) are attractive candidates for cell-based tissue repair approaches.
Hundreds of clinical trials using MSCs have been completed and many others are still being investigated.
For most therapeutic applications, MSC propagation in vitro is often required.
However, ex vivo culture condition is not fully physiological and may affect biological properties of MSCs including their regenerative potential.
Moreover, both cell cryopreservation and labelling procedure prior to infusion may have the negative impact on their expected effect in vivo.
The incidence of MSC transformation during in vitro culture should be also taken into consideration before using cells in stem cell therapy.
In our review, we focused on different aspects of MSC propagation that might influence their regenerative properties of MSC.
We also discussed the influence of different factors that might abolish MSC proliferation and differentiation as well as potential impact of stem cell senescence and aging.
Despite of many positive therapeutic effects of MSC therapy, one has to be conscious about potential cell changes that could appear during manufacturing of MSCs.
American Psychological Association (APA)
Drela, Katarzyna& Stanaszek, Luiza& Nowakowski, Adam& Kuczynska, Zuzanna& Lukomska, Barbara. 2019. Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1209417
Modern Language Association (MLA)
Drela, Katarzyna…[et al.]. Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1209417
American Medical Association (AMA)
Drela, Katarzyna& Stanaszek, Luiza& Nowakowski, Adam& Kuczynska, Zuzanna& Lukomska, Barbara. Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1209417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209417