Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat
Joint Authors
Zayed, Ahmed E.
Saleh, Ahmed
Gomaa, Asmaa M. S.
Abd-Elkareem, Mahmoud
Anwar, Mamdouh M.
Hassanein, Khaled M. A.
Elsherbiny, Mohsen M.
Kotb, Ahmed M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We aimed in our current study to explore the protective effect of Ginkgo biloba (GB) and magnetized water (MW) against nephrotoxicity associating induced type 2 diabetes mellitus in rat.
Here, we induced diabetes by feeding our lab rats on a high fat-containing diet (4 weeks) and after that injecting them with streptozotocin (STZ).
We randomly divided forty rats into four different groups: nontreated control (Ctrl), nontreated diabetic (Diabetic), Diabetic+GB (4-week treatment), and Diabetic+MW (4-week treatment).
After the experiment was finished, serum and kidney tissue samples were gathered.
Blood levels of glucose, triglycerides, cholesterol, creatinine, and urea were markedly elevated in the diabetic group than in the control group.
In all animals treated with GB and MW, the levels of urea, creatinine, and glucose were significantly reduced (all P<0.01).
GB and MW attenuated glomerular and tubular injury as well as the histological score.
Furthermore, they normalized the contents of glutathione reductase and SOD2.
In summary, our data showed that GB and MW treatment protected type 2 diabetic rat kidneys from nephrotoxic damages by reducing the hyperlipidemia, uremia, oxidative stress, and renal dysfunction.
American Psychological Association (APA)
Zayed, Ahmed E.& Saleh, Ahmed& Gomaa, Asmaa M. S.& Abd-Elkareem, Mahmoud& Anwar, Mamdouh M.& Hassanein, Khaled M. A.…[et al.]. 2018. Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210918
Modern Language Association (MLA)
Zayed, Ahmed E.…[et al.]. Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210918
American Medical Association (AMA)
Zayed, Ahmed E.& Saleh, Ahmed& Gomaa, Asmaa M. S.& Abd-Elkareem, Mahmoud& Anwar, Mamdouh M.& Hassanein, Khaled M. A.…[et al.]. Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210918