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Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
Joint Authors
Rady, Islam
Bloch, Melissa B.
Chamcheu, Roxane-Cherille N.
Banang Mbeumi, Sergette
Anwar, Md Rafi
Mohamed, Hadir
Kuiate, Jules-Roger
Noubissi, Felicite K.
Whitfield, G. Kerr
Chamcheu, Jean Christopher
El Sayed, Khalid
Babatunde, A. S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-39, 39 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
39
Main Subjects
Abstract EN
Graviola (Annona muricata) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in tropical and subtropical regions around the world.
The aerial parts of graviola have several functions: the fruits have been widely used as food confectionaries, while several preparations, especially decoctions of the bark, fruits, leaves, pericarp, seeds, and roots, have been extensively used in traditional medicine to treat multiple ailments including cancers by local communities in tropical Africa and South America.
The reported therapeutic benefits of graviola against various human tumors and disease agents in in vitro culture and preclinical animal model systems are typically tested for their ability to specifically target the disease, while exerting little or no effect on normal cell viability.
Over 212 phytochemical ingredients have been reported in graviola extracts prepared from different plant parts.
The specific bioactive constituents responsible for the major anticancer, antioxidant, anti-inflammatory, antimicrobial, and other health benefits of graviola include different classes of annonaceous acetogenins (metabolites and products of the polyketide pathway), alkaloids, flavonoids, sterols, and others.
This review summarizes the current understanding of the anticancer effects of A.
muricata and its constituents on diverse cancer types and disease states, as well as efficacy and safety concerns.
It also includes discussion of our current understanding of possible mechanisms of action, with the hope of further stimulating the development of improved and affordable therapies for a variety of ailments.
American Psychological Association (APA)
Rady, Islam& Bloch, Melissa B.& Chamcheu, Roxane-Cherille N.& Banang Mbeumi, Sergette& Anwar, Md Rafi& Mohamed, Hadir…[et al.]. 2018. Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-39.
https://search.emarefa.net/detail/BIM-1210928
Modern Language Association (MLA)
Rady, Islam…[et al.]. Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-39.
https://search.emarefa.net/detail/BIM-1210928
American Medical Association (AMA)
Rady, Islam& Bloch, Melissa B.& Chamcheu, Roxane-Cherille N.& Banang Mbeumi, Sergette& Anwar, Md Rafi& Mohamed, Hadir…[et al.]. Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-39.
https://search.emarefa.net/detail/BIM-1210928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210928