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Antihypertensive Effect of Ethanolic Extract from Acanthopanax sessiliflorus Fruits and Quality Control of Active Compounds
Joint Authors
Jung, In Ho
Kim, Sung Eun
Lee, Yeong-Geun
Kim, Dae Hyun
Kim, Haneul
Kim, Geum-Soog
Baek, Nam-In
Lee, Dae Young
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Acanthopanax sessiliflorus (Rupr.
& Maxim.) Seem., which belongs to the Araliaceae family, mainly inhabits Korea, China, and Japan.
Traditionally, Acanthopanax species have been used as treatment for several diseases such as diabetes, tumors, and rheumatoid arthritis.
Especially, its fruits have many biological functions including antitumor, immunostimulating, antithrombosis, and antiplatelet activities.
Recently, the extract of A.
sessiliflorus fruit has been reported to have antithrombotic and antiplatelet activities related to the alleviation of hypertension.
Therefore, we investigated the antihypertensive effect of ethanolic extract from A.
sessiliflorus fruits (DHP1501) through in vivo, ex vivo, and in vitro studies.
In this study, DHP1501 demonstrated free radical scavenging capacity, enhanced endothelial nitric oxide (NO) production, and inhibited angiotensin-converting enzyme (ACE) activity in spontaneously hypertensive rats (SHRs), resulting in the improvement of vascular relaxation and decrease in blood pressure in the hypertensive animal model.
These results suggest that A.
sessiliflorus fruit extract may be a promising functional material for the prevention and treatment of hypertension.
Furthermore, this study demonstrated the utility of MS-based active compounds for the quality control of DHP1501.
American Psychological Association (APA)
Jung, In Ho& Kim, Sung Eun& Lee, Yeong-Geun& Kim, Dae Hyun& Kim, Haneul& Kim, Geum-Soog…[et al.]. 2018. Antihypertensive Effect of Ethanolic Extract from Acanthopanax sessiliflorus Fruits and Quality Control of Active Compounds. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211578
Modern Language Association (MLA)
Jung, In Ho…[et al.]. Antihypertensive Effect of Ethanolic Extract from Acanthopanax sessiliflorus Fruits and Quality Control of Active Compounds. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211578
American Medical Association (AMA)
Jung, In Ho& Kim, Sung Eun& Lee, Yeong-Geun& Kim, Dae Hyun& Kim, Haneul& Kim, Geum-Soog…[et al.]. Antihypertensive Effect of Ethanolic Extract from Acanthopanax sessiliflorus Fruits and Quality Control of Active Compounds. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211578