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Effects of Redox Disturbances on Intestinal Contractile Reactivity in Rats Fed with a Hypercaloric Diet
Joint Authors
Diniz, Anderson Fellyp Avelino
dos Santos Ferreira, Elba
de Lima Tavares Toscano, Lydiane
Silva, Alexandre Sérgio
da Silva, Bagnólia Araújo
Queiroga, Fernando R.
da Silva, Patrícia M.
Cavalcante, Fabiana de A.
de Souza, Iara L. L.
Carvalho, Maria Thaynan de L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Few studies have associated the effects of changes in caloric intake and redox disturbances in the gastrointestinal tract.
Therefore, the present study aimed at evaluating the hypercaloric diet consumption influence on the contractile reactivity of intestinal smooth muscle, morphology, and oxidative stress of rat ileum.
Wistar rats were randomly divided into groups that received a standard diet and fed with a hypercaloric diet for 8 weeks.
Animals were euthanized, and the ileum was isolated to isotonic contraction monitoring.
Morphology was evaluated by histological staining and oxidative stress by quantification of malondialdehyde levels and total antioxidant activity.
Cumulative concentration-response curves to KCl and carbachol were attenuated in rats fed with a hypercaloric diet compared to those that received a standard diet.
In addition, an increase in caloric intake promotes a rise in the thickness of the longitudinal smooth muscle layer of rat ileum and tissue malondialdehyde levels, characterizing lipid peroxidation, as well as a decrease in the antioxidant activity.
Thus, it was concluded that the consumption of a hypercaloric diet impairs rat intestinal contractility due to mechanisms involving modifications in the intestinal smooth muscle architecture triggered by redox disturbances.
American Psychological Association (APA)
de Souza, Iara L. L.& dos Santos Ferreira, Elba& Diniz, Anderson Fellyp Avelino& Carvalho, Maria Thaynan de L.& Queiroga, Fernando R.& de Lima Tavares Toscano, Lydiane…[et al.]. 2018. Effects of Redox Disturbances on Intestinal Contractile Reactivity in Rats Fed with a Hypercaloric Diet. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211790
Modern Language Association (MLA)
de Souza, Iara L. L.…[et al.]. Effects of Redox Disturbances on Intestinal Contractile Reactivity in Rats Fed with a Hypercaloric Diet. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211790
American Medical Association (AMA)
de Souza, Iara L. L.& dos Santos Ferreira, Elba& Diniz, Anderson Fellyp Avelino& Carvalho, Maria Thaynan de L.& Queiroga, Fernando R.& de Lima Tavares Toscano, Lydiane…[et al.]. Effects of Redox Disturbances on Intestinal Contractile Reactivity in Rats Fed with a Hypercaloric Diet. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211790