No Additive Effects of Polyphenol Supplementation and Exercise Training on White Adiposity Determinants of High-Fat Diet-Induced Obese Insulin-Resistant Rats
Joint Authors
Lambert, Karen
Hokayem, Marie
Fabre, Odile
Cassan, Cécile
Bourret, Annick
Bernex, Florence
Lees, Jessica
Demion, Marie
Seyer, Pascal
Hugon, Gérald
Mercier, Jacques
Bisbal, Catherine
Avignon, A.
Thomas, Claire
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
One of the major insulin resistance instigators is excessive adiposity and visceral fat depots.
Individually, exercise training and polyphenol intake are known to exert health benefits as improving insulin sensitivity.
However, their combined curative effects on established obesity and insulin resistance need further investigation particularly on white adipose tissue alterations.
Therefore, we compared the effects on different white adipose tissue depot alterations of a combination of exercise and grape polyphenol supplementation in obese insulin-resistant rats fed a high-fat diet to the effects of a high-fat diet alone or a nutritional supplementation of grape polyphenols (50 mg/kg/day) or exercise training (1 hr/day to 5 days/wk consisting of treadmill running at 32 m/min for a 10% slope), for a total duration of 8 weeks.
Separately, polyphenol supplementation and exercise decreased the quantity of all adipose tissue depots and mesenteric inflammation.
Exercise reduced adipocytes’ size in all fat stores.
Interestingly, combining exercise to polyphenol intake presents no more cumulative benefit on adipose tissue alterations than exercise alone.
Insulin sensitivity was improved at systemic, epididymal, and inguinal adipose tissues levels in trained rats thus indicating that despite their effects on adipocyte morphological/metabolic changes, polyphenols at nutritional doses remain less effective than exercise in fighting insulin resistance.
American Psychological Association (APA)
Lambert, Karen& Hokayem, Marie& Thomas, Claire& Fabre, Odile& Cassan, Cécile& Bourret, Annick…[et al.]. 2018. No Additive Effects of Polyphenol Supplementation and Exercise Training on White Adiposity Determinants of High-Fat Diet-Induced Obese Insulin-Resistant Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211976
Modern Language Association (MLA)
Lambert, Karen…[et al.]. No Additive Effects of Polyphenol Supplementation and Exercise Training on White Adiposity Determinants of High-Fat Diet-Induced Obese Insulin-Resistant Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211976
American Medical Association (AMA)
Lambert, Karen& Hokayem, Marie& Thomas, Claire& Fabre, Odile& Cassan, Cécile& Bourret, Annick…[et al.]. No Additive Effects of Polyphenol Supplementation and Exercise Training on White Adiposity Determinants of High-Fat Diet-Induced Obese Insulin-Resistant Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211976