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Efficacy and Safety of Botulinum Toxin Type A in Treating Patients of Advanced Age with Idiopathic Trigeminal Neuralgia
Joint Authors
Luo, Wei-Feng
Liu, Jing
Xu, Ying-Ying
Zhang, Qi-Lin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To assess the therapeutic efficacy and safety of botulinum toxin type A (BTX-A) for treating idiopathic trigeminal neuralgia (ITN) in patients ≥80 years old.
Methods.
Selected patients n=43 with ITN, recruited from the neurology clinic and inpatient department of the Second Affiliated Hospital of Soochow University between August 2008 and February 2014, were grouped by age, one subset n=14 ≥80 years old and another n=29 <60 years old.
Each group scored similarly in degrees of pain registered by the visual analogue scale (VAS).
Dosing, efficacy, and safety of BTX-A injections were compared by group.
Results.
Mean dosages of BTX-A were 91.3 ± 25.6 U and 71.8 ± 33.1 U in older and younger patients, respectively t=1.930, p=0.061.
The median of the VAS score in older patients at baseline (8.5) declined significantly at 1 month after treatment (4.5) p=0.007, as did that of younger patients (8.0 and 5.0, resp.) p=0.001.
The median of the D values of the VAS scores did not differ significantly by group (older, 2.5; younger, 0; Z=−1.073, p=0.283).
Two patients in each group developed minor transient side effects p=0.825.
Adverse reactions in both groups were mild, resolving spontaneously within 3 weeks.
Conclusions.
BTX-A is effective and safe in treating patients of advanced age (≥80 years old) with ITN, at dosages comparable to those used in much younger counterparts (<60 years old).
American Psychological Association (APA)
Liu, Jing& Xu, Ying-Ying& Zhang, Qi-Lin& Luo, Wei-Feng. 2018. Efficacy and Safety of Botulinum Toxin Type A in Treating Patients of Advanced Age with Idiopathic Trigeminal Neuralgia. Pain Research and Management،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1212601
Modern Language Association (MLA)
Liu, Jing…[et al.]. Efficacy and Safety of Botulinum Toxin Type A in Treating Patients of Advanced Age with Idiopathic Trigeminal Neuralgia. Pain Research and Management No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1212601
American Medical Association (AMA)
Liu, Jing& Xu, Ying-Ying& Zhang, Qi-Lin& Luo, Wei-Feng. Efficacy and Safety of Botulinum Toxin Type A in Treating Patients of Advanced Age with Idiopathic Trigeminal Neuralgia. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1212601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212601