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Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats
Joint Authors
Oliveira, L. D.
Cardoso de Sousa, Michelle
Vegian, Mariana Raquel da Cruz
Biserra, Matheus Alves
Costa, Bruno César Almeida
Camargo, Samira Esteves Afonso
Rode, Sigmar de Mello
Ramos, Carolina Judica
Vasconcellos, Luana Marotta Reis de
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Chronic alcohol exposure can affect the osteoblastic activity and the proliferation and differentiation of cells due to its toxic effect, which can affect negatively bone repair and bone microarchitecture.
The aim of this study was to evaluate the effects of chronic use of 20% alcohol on rats regarding osteoblastic differentiation, extrinsic and intrinsic properties of the tibia, and hepatic and renal morphology.
Wistar rats were divided into three groups (n=9) in accordance with a 24-week diet.
After euthanasia, kidneys, liver, and tibias were removed for analysis and femurs mesenchymal cells were collected.
The results showed that chronic use of 20% alcohol influenced neither the alkaline phosphatase production nor total protein (p>0.05) in rats, with similar formation of nodules in all groups (p>0.05).
However, significant changes in the liver and kidneys and adverse effects on the mechanical properties of the tibia were observed.
According to the results, it can be concluded that the chronic use of alcohol for 24 weeks had no negative influence on the activity and differentiation of osteoblasts, but the mechanical properties of the tibia were impaired and the organs responsible for metabolism and excretion were also affected due to the consumption of alcohol.
American Psychological Association (APA)
Cardoso de Sousa, Michelle& Vegian, Mariana Raquel da Cruz& Biserra, Matheus Alves& Costa, Bruno César Almeida& Camargo, Samira Esteves Afonso& Rode, Sigmar de Mello…[et al.]. 2018. Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1215609
Modern Language Association (MLA)
Cardoso de Sousa, Michelle…[et al.]. Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats. The Scientific World Journal No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1215609
American Medical Association (AMA)
Cardoso de Sousa, Michelle& Vegian, Mariana Raquel da Cruz& Biserra, Matheus Alves& Costa, Bruno César Almeida& Camargo, Samira Esteves Afonso& Rode, Sigmar de Mello…[et al.]. Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1215609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1215609