Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria
Joint Authors
Oyedemi, Sunday O.
Oyedemi, Blessing O.
Chibuzor, Johnson V.
Ijeh, Ifeoma I.
Coopoosamy, Roger M.
Aiyegoro, Ayobami O.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Oral and skin infections contribute significantly to the global health challenges responsible for the current trend of increased morbidity and premature death.
The purpose of this study was to document medicinal plants used in the management of oral and skin infections in Ebem-Ohafia Local Government Area (LGA), Abia State, and to characterize the in vitro antioxidant and antibacterial activity.
The thin layer chromatography (TLC) profiling of ten of the selected folklore medicine was carried out using a various solvent system of different polarity index.
The antioxidant capacity of the plant extracts was evaluated using chemical-based methods, and its antibacterial effect was investigated using disc diffusion and microdilution methods.
Sixty-one plant species belonging to 26 families were discovered, and the most frequently cited species are Euphorbiaceae (18.03%), Fabaceae (11.47%), and Asteraceae (11.47%).
All the plant extracts showed a promising free radical scavenging activity and efficient ferric reducing antioxidant power in a concentration-dependent manner possibly due to their richness in polyphenol with TLC profiling showing maximum three bands of phytochemicals.
Also, the plant extracts exhibited a mild to weak antibacterial activity against our panel of bacterial strains having MIC values ranging from 256 to > 512 μg/ mL reflected in their zone of inhibition at 10 μg/disc.
The data obtained for Breynia nivosa (BN), Eleusine indica (EI), Cassia alata (CA), Chromolaena odorata (CO), and Acalypha hispida (AH) extracts substantiate the traditional use of these herbal remedies in the region and open the possibility for the development of cheaper and affordable drugs in the treatment of oral and skin infections.
Further studies are needed to identify active ingredient with strong antibacterial and antioxidant capacities along with their molecular mechanisms.
American Psychological Association (APA)
Oyedemi, Blessing O.& Oyedemi, Sunday O.& Chibuzor, Johnson V.& Ijeh, Ifeoma I.& Coopoosamy, Roger M.& Aiyegoro, Ayobami O.. 2018. Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1215625
Modern Language Association (MLA)
Oyedemi, Blessing O.…[et al.]. Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria. The Scientific World Journal No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1215625
American Medical Association (AMA)
Oyedemi, Blessing O.& Oyedemi, Sunday O.& Chibuzor, Johnson V.& Ijeh, Ifeoma I.& Coopoosamy, Roger M.& Aiyegoro, Ayobami O.. Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1215625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1215625