Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients
Joint Authors
Sezer, Siren
Erkmen Uyar, Mehtap
Tutal, Emre
Bal, Zeynep
Demirci, Bahar Gurlek
Karakose, Suleyman
Acar, Nurhan Ozdemir
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
We aimed to investigate the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients.
Methods.
One hundred and sixty-nine patients during the entire 12 months were enrolled into the study.
Fasting plasma glucose, creatinine, calcium, phosphorus, alkaline phosphatase, parathyroid hormone (PTH), C-reactive protein (CRP), serum iron, serum iron-binding capacity, and transferrin saturation were analyzed.
We defined six groups: low, target range, high, low-amplitude fluctuation with low hemoglobin levels, low-amplitude fluctuation with high hemoglobin levels, and high-amplitude fluctuation.
Body mass index (BMI), malnutrition-inflammation score (MIS), and Charlson Comorbidity Index were evaluated.
Results.
Hemoglobin variability was significantly correlated with age, platelet count, and number of hospitalization instances and inversely correlated with erythropoietin dose per body surface area.
The coefficient of variation of hemoglobin showed a correlation with MIS and ferritin.
The absolute level of hemoglobin showed a negative correlation between PTH, CRP, MIS, number of hospitalization instances and a positive correlation with albumin and BMI.
High, low, and target-range groups showed survival advantage compared to the other three groups.
In regression analysis, age, CRP levels, MIS, and BMI were the predictors of mortality.
Conclusion.
Inflammation and duration of anemia were the major predictors of hemoglobin variability.
High-amplitude fluctuation predicts high mortality; on the contrary low-amplitude fluctuations is related to better survival.
MIS was independently associated with mortality.
This trial is registered with NCT03454906.
American Psychological Association (APA)
Bal, Zeynep& Demirci, Bahar Gurlek& Karakose, Suleyman& Tutal, Emre& Erkmen Uyar, Mehtap& Acar, Nurhan Ozdemir…[et al.]. 2018. Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1215664
Modern Language Association (MLA)
Bal, Zeynep…[et al.]. Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients. The Scientific World Journal No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1215664
American Medical Association (AMA)
Bal, Zeynep& Demirci, Bahar Gurlek& Karakose, Suleyman& Tutal, Emre& Erkmen Uyar, Mehtap& Acar, Nurhan Ozdemir…[et al.]. Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1215664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1215664