Molecular localization of human papillomaviru_18 (HPV_18) in tissues from thyroid carcinoma in mid-euphrates
Joint Authors
Ali, Sad Hasan Muhammad
al-Ujayli, Usamah Abd al-Qadum
Abd al-Amir, A. A. Amber H.
Muhammad, Shakir M.
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 6 (30 Jun. 2018), pp.84-94, 11 p.
Publisher
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
Background: THilnahyroid cancer is a cancer that starts in the thyroid gland and thought to be relatedtoanumberof environmental andgeneticpredisposingfactors .HumanPapil- loma Virus (HPV) the virus that causes cervical cancer ,is also linked to throat cancer and is one among theirassociatedinfectiveagents.
Objective: This study aimed at detecting DNA of HPV genotype-18 using in situ hybridization technique in thyroid tissues from benign thyroid hyperplasia and thyroid car- cinoma,andelucidatetheassociationbetweenthisHPV-18andthyroidcarcinogenesis.
Patients and Methods: Sixty (60) formalin-fixed, paraffin embedded thyroid tissue blocks were obtained ,among them (30) tissue biopsies from thyroid carcinoma with grade I and (20) benign thyroid neoplasm tissue blocks as well as (10) autopsies from apparently normal thyroid tissues were collected from the archives of Forensic Medicine Institute / Babil and used as thyroid healthy control group.
Detection of HPV-18 was done by using highly sensitive version of in situ hybridization technique.
Results: Among malignant thyroid tumors 56.7% patients had HPV-18 while 35% HPV- 18 positivity was detected in benign thyroid tumor group.
None of healthy thyroid tissues revealed ISH reactions.
There was 32.7% female had HPV-18, and 24% male had HPV-18.
Nosignificant statistical associations were noticed between the presence of HPV-18 and the age of those patients.
Conclusion: Human Papilloma-
American Psychological Association (APA)
Muhammad, Shakir M.& Abd al-Amir, A. A. Amber H.& Ali, Sad Hasan Muhammad& al-Ujayli, Usamah Abd al-Qadum. 2018. Molecular localization of human papillomaviru_18 (HPV_18) in tissues from thyroid carcinoma in mid-euphrates. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 6, pp.84-94.
https://search.emarefa.net/detail/BIM-1221270
Modern Language Association (MLA)
Muhammad, Shakir M.…[et al.]. Molecular localization of human papillomaviru_18 (HPV_18) in tissues from thyroid carcinoma in mid-euphrates. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 6 (2018), pp.84-94.
https://search.emarefa.net/detail/BIM-1221270
American Medical Association (AMA)
Muhammad, Shakir M.& Abd al-Amir, A. A. Amber H.& Ali, Sad Hasan Muhammad& al-Ujayli, Usamah Abd al-Qadum. Molecular localization of human papillomaviru_18 (HPV_18) in tissues from thyroid carcinoma in mid-euphrates. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 6, pp.84-94.
https://search.emarefa.net/detail/BIM-1221270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 92-93
Record ID
BIM-1221270