Therapeutic effects of Baobab fruit pulp (Adansonia digitata)‎ aqueous extract on liver and cardiovascular system of high-fat diet rat model

Abstract EN

This study examined baobab fruit pulp (BFP) therapeutic effects on liver and cardiovascular in high fat diet(HFD) rats.

Sixty male rats classified into ; negative control, HFD.

BFP, HFD+LDBFP, HFD+HDBFP, and HFD+Statin.

at end, rats sacrificed ; liver, heart and coronary arteries examined histopathological and blood samples withdrawn for measurement of blood glucose ; lipid profiles [total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), LDL-C, vLDL-C] ; liver functions [aspartate aminotransaminase (AST), alkaline phosphatase (ALP), alanine aminotransaminase (ALT), albumin, total protein (TP)] ; cardiac enzymes [creatinine kinase-MB (CK-MB), troponin] ; oxidative stress [malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD)].

Blood glucose and TC, LDL-C, TG, and vLDL-C, AST, ALT, ALP, CK-MB, troponin, MAD serum levels were higher; while HDL-C, total proteins, albumin, SOD, GSH were lowered in HFD versus other groups ; they ameliorated with HDBFP and Statin.

biochemical changes confirmed histopathological observations.

in conclusion, HDBFP slow hypercholesterolemiainduced oxidative stress via its antioxidant capacity.