Acute kidney injuries in children with severe malaria : a comparative study of diagnostic criteria based on serum cystatin C and creatinine levels
Other Title(s)
إصابات الكلى الحادة عند الأطفال المصابين بملاريا حادة : دراسة مقارنة للمعايير التشخيصية المبنية على قياس تركيزي السيستاتين سي و الكرياتنين في مصل الدم
Joint Authors
Afolayan, Folake Moriliat
Adedoyin, Olanrewaju Timothy
Abd al-Qadir, Muhammad Baba
Ibrahim, Olayinka Rashid
Biliaminu, Sikiru A.
Mokuolu, Olugbenga A.
Ojuawo, Ayodele
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 20, Issue 4 (30 Nov. 2020), pp.312-317, 6 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2020-11-30
Country of Publication
Oman
No. of Pages
6
Main Subjects
Abstract EN
Objectives: Serum creatinine levels are often used to diagnose acute kidney injury (AKI), but may not necessarily accurately reflect changes in glomerular filtration rate (GFR).
This study aimed to compare the prevalence of AKI in children with severe malaria using diagnostic criteria based on creatinine values in contrast to cystatin C.
Methods: This prospective cross-sectional study was performed between June 2016 and May 2017 at the University of Ilorin Teaching Hospital, Ilorin, Nigeria.
A total of 170 children aged 0.5–14 years old with severe malaria were included.
Serum cystatin C levels were determined using a particle-enhanced immunoturbidmetric assay method, while creatinine levels were measured using the Jaffe reaction.
Renal function assessed using cystatin C-derived estimated GFR (eGFR) was compared to that measured using three sets of criteria based on creatinine values including the Kidney Disease: Improved Global Outcomes (KDIGO) and World Health Organization (WHO) criteria as well as an absolute creatinine cut-off value of >1.5 mg/dL.
Results: Mean serum cystatin C and creatinine levels were 1.77 ± 1.37 mg/L and 1.23 ± 1.80 mg/dL, respectively (P = 0.002).
According to the KDIGO, WHO and absolute creatinine criteria, the frequency of AKI was 32.4%, 7.6% and 16.5%, respectively.
In contrast, the incidence of AKI based on cystatin C-derived eGFR was 51.8%.
Overall, the rate of detection of AKI was significantly higher using cystatin C compared to the KDIGO, WHO and absolute creatinine criteria (P = 0.003, <0.001 and <0.001, respectively).
Conclusion: Diagnostic criteria for AKI based on creatinine values may not indicate the actual burden of disease in children with severe malaria.
American Psychological Association (APA)
Afolayan, Folake Moriliat& Adedoyin, Olanrewaju Timothy& Abd al-Qadir, Muhammad Baba& Ibrahim, Olayinka Rashid& Biliaminu, Sikiru A.& Mokuolu, Olugbenga A.…[et al.]. 2020. Acute kidney injuries in children with severe malaria : a comparative study of diagnostic criteria based on serum cystatin C and creatinine levels. Sultan Qaboos University Medical Journal،Vol. 20, no. 4, pp.312-317.
https://search.emarefa.net/detail/BIM-1342892
Modern Language Association (MLA)
Afolayan, Folake Moriliat…[et al.]. Acute kidney injuries in children with severe malaria : a comparative study of diagnostic criteria based on serum cystatin C and creatinine levels. Sultan Qaboos University Medical Journal Vol. 20, no. 4 (Nov. 2020), pp.312-317.
https://search.emarefa.net/detail/BIM-1342892
American Medical Association (AMA)
Afolayan, Folake Moriliat& Adedoyin, Olanrewaju Timothy& Abd al-Qadir, Muhammad Baba& Ibrahim, Olayinka Rashid& Biliaminu, Sikiru A.& Mokuolu, Olugbenga A.…[et al.]. Acute kidney injuries in children with severe malaria : a comparative study of diagnostic criteria based on serum cystatin C and creatinine levels. Sultan Qaboos University Medical Journal. 2020. Vol. 20, no. 4, pp.312-317.
https://search.emarefa.net/detail/BIM-1342892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 317
Record ID
BIM-1342892