Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer

Joint Authors

Jain, Anjali
al-Hatimi, Asma
Mittal, Alok Kumar
Husayn, Samir

Source

Sultan Qaboos University Medical Journal

Issue

Vol. 22, Issue 1 (28 Feb. 2022), pp.74-81, 8 p.

Publisher

Sultan Qaboos University College of Medicine and Health Sciences

Publication Date

2022-02-28

Country of Publication

Oman

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Objectives: This study aimed to investigate the value of single photon emission computed tomography/ computed tomography (SPECT/CT) imaging in well-differentiated thyroid cancer (DTC) after radioiodine (I-131) ablation/therapy for clinical staging and risk stratification.

It also aimed to determine whether SPECT/CT would change the management plan or predict the clinical outcomes of DTC patients.

Methods: A total of 78 DTC patients underwent first post radioiodine therapy “Whole body iodine-131 scintigraphy (WBS) along with SPECT/CT” at the Department of Radiology and Molecular imaging, Sultan Qaboos University Hospital, Muscat, Oman, between January 2014 and August 2017.

Differences between WBS and SPECT/CT, change in clinical staging, risk stratification and management were recorded.

The clinical outcome at 6–12 months was recorded.

A generalised McNemar test was used to assess disagreement between WBS and SPECT/CT.

Results: According to the American Thyroid Association (ATA) risk stratification, the sample showed low (35.8%), intermediate (53.8%) and high-risk groups (10.2%) on WBS, which changed to 44.8%, 38.4% and 16.6%, respectively, on SPECT/CT imaging.

Overall change in risk stratification was noted in 16.7% and TNM stage in 11.5% of patients after SPECT/CT imaging.

SPECT/CT changed the therapeutic plan and clinical outcome in 19.2% of patients.

Conclusion: SPECT/CT allows better detection and characterisation of metastatic lymph nodes and distant metastasis in DTC patients compared to WBS imaging alone.

It alters TNM staging, ATA risk classification and management in a significant number of patients.

It is recommended that SPECT/ CT should be done routinely along with WBS in well-differentiated thyroid carcinoma.

American Psychological Association (APA)

al-Hatimi, Asma& Jain, Anjali& Mittal, Alok Kumar& Husayn, Samir. 2022. Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer. Sultan Qaboos University Medical Journal،Vol. 22, no. 1, pp.74-81.
https://search.emarefa.net/detail/BIM-1343802

Modern Language Association (MLA)

Husayn, Samir…[et al.]. Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer. Sultan Qaboos University Medical Journal Vol. 22, no. 1 (Feb. 2022), pp.74-81.
https://search.emarefa.net/detail/BIM-1343802

American Medical Association (AMA)

al-Hatimi, Asma& Jain, Anjali& Mittal, Alok Kumar& Husayn, Samir. Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer. Sultan Qaboos University Medical Journal. 2022. Vol. 22, no. 1, pp.74-81.
https://search.emarefa.net/detail/BIM-1343802

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 80-81

Record ID

BIM-1343802