Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer
Mittal, Alok Kumar
Sultan Qaboos University Medical Journal
Vol. 22, Issue 1 (28 Feb. 2022), pp.74-81, 8 p.
Sultan Qaboos University College of Medicine and Health Sciences
Country of Publication
No. of Pages
Objectives: This study aimed to investigate the value of single photon emission computed tomography/ computed tomography (SPECT/CT) imaging in well-differentiated thyroid cancer (DTC) after radioiodine (I-131) ablation/therapy for clinical staging and risk stratification.
It also aimed to determine whether SPECT/CT would change the management plan or predict the clinical outcomes of DTC patients.
Methods: A total of 78 DTC patients underwent first post radioiodine therapy “Whole body iodine-131 scintigraphy (WBS) along with SPECT/CT” at the Department of Radiology and Molecular imaging, Sultan Qaboos University Hospital, Muscat, Oman, between January 2014 and August 2017.
Differences between WBS and SPECT/CT, change in clinical staging, risk stratification and management were recorded.
The clinical outcome at 6–12 months was recorded.
A generalised McNemar test was used to assess disagreement between WBS and SPECT/CT.
Results: According to the American Thyroid Association (ATA) risk stratification, the sample showed low (35.8%), intermediate (53.8%) and high-risk groups (10.2%) on WBS, which changed to 44.8%, 38.4% and 16.6%, respectively, on SPECT/CT imaging.
Overall change in risk stratification was noted in 16.7% and TNM stage in 11.5% of patients after SPECT/CT imaging.
SPECT/CT changed the therapeutic plan and clinical outcome in 19.2% of patients.
Conclusion: SPECT/CT allows better detection and characterisation of metastatic lymph nodes and distant metastasis in DTC patients compared to WBS imaging alone.
It alters TNM staging, ATA risk classification and management in a significant number of patients.
It is recommended that SPECT/ CT should be done routinely along with WBS in well-differentiated thyroid carcinoma.
American Psychological Association (APA)
al-Hatimi, Asma& Jain, Anjali& Mittal, Alok Kumar& Husayn, Samir. 2022. Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer. Sultan Qaboos University Medical Journal،Vol. 22, no. 1, pp.74-81.
Modern Language Association (MLA)
al-Hatimi, Asma…[et al.]. Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer. Sultan Qaboos University Medical Journal Vol. 22, no. 1 (Feb. 2022), pp.74-81.
American Medical Association (AMA)
al-Hatimi, Asma& Jain, Anjali& Mittal, Alok Kumar& Husayn, Samir. Evaluation of diagnostic value of SPECT-CT imaging in post-radioiodine therapy in thyroid cancer. Sultan Qaboos University Medical Journal. 2022. Vol. 22, no. 1, pp.74-81.
Includes bibliographical references : p. 80-81
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