Pregnancy outcomes in systemic lupus erythematosus women : a single tertiary centre experience
Joint Authors
Hasan, Batul Ali
Salman, Bushra
al-Rashidi, Amani
al-Haddabi, Rahmah
al-Dughaishi, Tamima
al-Riyami, Nihal
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 21, Issue 2 (31 May. 2021), pp.244-252, 9 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2021-05-31
Country of Publication
Oman
No. of Pages
9
Main Subjects
Abstract EN
Objectives : this study was conducted to assess pregnancy outcomes in women with systemic lupus erythematosus (SLE) in Oman.
methods : a retrospective cohort study of 149 pregnancies in 98 women with SLE was conducted over 10 years to evaluate the impact of clinical and laboratory parameters in predicting adverse pregnancy outcomes.
results : mean maternal age was 30.6 ± 5 years ranging from 20–44 years, and the mean disease duration was 10 ± 5 years, ranging from 2–27 years.
the most common maternal manifestations were joint pain in 36 (24.2%), lupus nephritis (LN) in 18 (12.08%), preeclampsia in 11 (7.4%), eclampsia in three (2%) and lupus flare in one pregnancy.
the live birth rate was 139 (93.3%) with a mean gestational age of 36 ± 2 weeks ranging from 26–40 weeks.
in total, 55 (39.6%) were preterm deliveries, six (4%) pregnancies ended in miscarriage, and four (2.7%) resulted in intrauterine fetal death.
Intrauterine growth restriction was observed in 49 babies(35%).
A significant association was found between hypertension (HTN) and miscarriage (P = 0.024) and preterm birth (P = 0.019).
In addition, HTN was positively associated with preeclampsia (P = 0.004) and LN (P = 0.048).
antiphospholipid syndrome impacted preterm birth (P = 0.013) and postpartem haemorrhage (PPH) (P = 0.027) and was found to be a significant predictor for women developing deep vein thrombosis and pulmonary embolism(P <0.001 for both).
conclusion : despite potential complications, most pregnancies complicated by SLE in Oman result in good outcomes.
adverse pregnancy outcomes, however, may still occur in women with SLE.
In women with SLE, pregnancy planning, careful antenatal monitoring and efficient SLE treatment need to be undertaken for successful pregnancy outcomes.
American Psychological Association (APA)
al-Riyami, Nihal& Salman, Bushra& al-Rashidi, Amani& al-Dughaishi, Tamima& al-Haddabi, Rahmah& Hasan, Batul Ali. 2021. Pregnancy outcomes in systemic lupus erythematosus women : a single tertiary centre experience. Sultan Qaboos University Medical Journal،Vol. 21, no. 2, pp.244-252.
https://search.emarefa.net/detail/BIM-1344810
Modern Language Association (MLA)
al-Haddabi, Rahmah…[et al.]. Pregnancy outcomes in systemic lupus erythematosus women : a single tertiary centre experience. Sultan Qaboos University Medical Journal Vol. 21, no. 2 (May. 2021), pp.244-252.
https://search.emarefa.net/detail/BIM-1344810
American Medical Association (AMA)
al-Riyami, Nihal& Salman, Bushra& al-Rashidi, Amani& al-Dughaishi, Tamima& al-Haddabi, Rahmah& Hasan, Batul Ali. Pregnancy outcomes in systemic lupus erythematosus women : a single tertiary centre experience. Sultan Qaboos University Medical Journal. 2021. Vol. 21, no. 2, pp.244-252.
https://search.emarefa.net/detail/BIM-1344810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 251-252
Record ID
BIM-1344810