A comparative pharmacokinetic study of two marketed ciprofloxacin tablet formulations using microbiological assay

Abstract EN

A comparative pharmacokinetics study of two ciprofloxacin conventional formulation was carried out on ten healthy male volunteers.

The study was randomized, with two way crossover design.

The agar well diffusion technique was applied for the assay of ciprofloxacin where plasma drug level was used as a parameter.

In vitro studies, it was illustrated that the two tablet formulation, were pharmaceutically equivalent.

In vivo studies, pharmacokinetic parameters, such as Cmax, median Tmax, and AUC0- ?, K, F Cl , F Vd and plasma half time T½ were determined and subjected to statistical analysis .

No significant difference in the rate or extent of absorption was observed between the two products.

Therefore, the two marketed ciprofloxacin tablet formulations delivered equal amounts of the drug to the systemic circulation