Shogaol potentiates sevoflurane mediated neuroprotection against ischemia-reperfusion-induced brain injury via regulating apoptotic proteins and PI3K-Akt-mTOR-s6K signalling and HIF-1α-HO-1 expression
Joint Authors
Zhang, Hui
Wang, Fang
Li, Lu
Jia, Shuhong
Zhang, Baoping
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 9 (30 Sep. 2021), pp.5002-5010, 9 p.
Publisher
Publication Date
2021-09-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
The current research was intended to evaluate the impact of 6-shogaol in rodent model of ischemic-reperfusion induced- brain injury and also assessed 6-shogaol enhanced sevoflurane's neuroprotective effects.
Ischemic-Reperfusion (I/R) injury was induced by middle cerebral artery occlusion (MCAO) method in Sprague-Dawley rats.
A separate group of animal was exposed to sevoflurane (2.5%) post-conditioning for 1 h immediately after reperfusion.
The 6-shogaol (25 mg or 50 mg/kg body weight) was orally administered to treatment group rats for 14 days and then subjected to I/R.
The 6-shogaol treatment along with/without sevoflurane post-conditioning reduced the number of apoptotic cell counts, brain edema and cerebral infarct volume.
The western blotting analysis revealed a significant stimulation of the PI3K/Akt/mTOR signal pathway.
RT-PCR and western blotting studies revealed improved expressions of HIF-1α and HO-1 at both gene level and protein levels.
I/R induced neurological deficits were also alleviated on sevoflurane post-conditioning with/without 6-shogaol treatment.
The present findings revealed that pre-treatment with 6-shogoal enhanced the neuroprotective properties of sevoflurane post-conditioning, illustrated the efficacy of the compound against I/R injury.
American Psychological Association (APA)
Jia, Shuhong& Zhang, Hui& Li, Lu& Wang, Fang& Zhang, Baoping. 2021. Shogaol potentiates sevoflurane mediated neuroprotection against ischemia-reperfusion-induced brain injury via regulating apoptotic proteins and PI3K-Akt-mTOR-s6K signalling and HIF-1α-HO-1 expression. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.5002-5010.
https://search.emarefa.net/detail/BIM-1410143
Modern Language Association (MLA)
Jia, Shuhong…[et al.]. Shogaol potentiates sevoflurane mediated neuroprotection against ischemia-reperfusion-induced brain injury via regulating apoptotic proteins and PI3K-Akt-mTOR-s6K signalling and HIF-1α-HO-1 expression. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.5002-5010.
https://search.emarefa.net/detail/BIM-1410143
American Medical Association (AMA)
Jia, Shuhong& Zhang, Hui& Li, Lu& Wang, Fang& Zhang, Baoping. Shogaol potentiates sevoflurane mediated neuroprotection against ischemia-reperfusion-induced brain injury via regulating apoptotic proteins and PI3K-Akt-mTOR-s6K signalling and HIF-1α-HO-1 expression. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.5002-5010.
https://search.emarefa.net/detail/BIM-1410143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5010
Record ID
BIM-1410143