Stereotactic radiosurgery (SRS)‎ experience on brain metastases : a 3-year retrospective study at King Abdulaziz University Hospital

Abstract EN

Objectives: Stereotactic radiosurgery (SRS), a non-invasive surgical procedure had been utilized for treatment of patients with brain metastases.

This study aims to determine the survival, local control of brain metastases and treatment outcome to SRS-treated patients based on radiological imaging.

Methods: The MRI scans of SRS-treated patients with brain metastases (n = 24) from the Radiology Department of King Abdulaziz University from January 2016 to September 2019 were examined.

The data was analyzed using descriptive statistics and Chi-square test.

Results: Out of 24 patients, most had brain metastases (95.8%, n = 23) with mean interval development (after primary site) of 21.88 ± 25.2 months.

Radiological imaging revealed tumor characteristics of smallest (n = 11) and biggest lesions (n = 24) of patients to be 0.98 ± 0.7 and 2.23 ± 0.9, respectively and number of lesion to be 4-5 lesions (n = 3), 3 lesions (n = 6), 2 lesions (n = 4) and 1 lesion (n = 11).

After SRS treatment, findings showed 17.6% (n = 3) no recurrence among the patients.

Those with recurrences have decrease in lesion enhancement (11.8%, n = 2), decrease in size (29.4%, n = 5) and decrease in both enhancement and size (29.4%).

Overall survival obtained was 16.7% (n = 2) at 313.83 ± 376.0 days (n = 23) survival period.

Chi-square test showed that radiological findings were significantly associated with tumor recurrence (p = 0.010), having SRS-treated patients with recurrences (n = 12) to experience significant decrease (p = 0.010) in tumor enhancement, size, and both enhancement and size.

Conclusion: A significant decrease in tumor size and enhancement was observed in SRS-treated patients, suggesting SRS treatment to have associated benefit with prolonged survival duration.