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Molecular adaptive evolution of SARS-COV-2 spike protein in Saudi Arabia
Joint Authors
Hanif, Atif
Ifan, Salih A.
Nur, Islam
al-Anzi, Ibrahim Uqlah
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 6 (30 Jun. 2021), pp.3325-3332, 8 p.
Publisher
Publication Date
2021-06-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
The sequences of SARS-CoV-2 spike (S) from Saudi Arabia along with SARS-CoV and bat SARS-like CoVs were obtained.
Positive selection analysis and secondary structure investigation of spike sequences were performed.
adaptive molecular evolution was observed in SARS-CoV-2 displayed by positive selection pressure at n-terminal domain (NTD; codons 41, 163, 174 and 218), receptor binding domain (RBD; codons 378 and 404) and S1/S2 Cleavage site (codon 690).
furthermore, the spike protein secondary structure depicted by the homo-trimer structure showed a high similarity between Saudi SARS-CoV-2 isolate and the parental strain (bat SL-COVZC45).
Despite the high similarity depicted in the spike sequence model alignment, it displayed a significant difference when each chain was treated solely owing to 7 motif differences in the three composing chains.
in addition, SARS-CoV-2 S trimer model uncovered the presence of n-acetyl glucosamine ligands.
eventually, 3C-like proteinase cleavage site was observed in s2 domain could be used as a site for drug discovery.
genetics and molecular evolutionary facts are useful for assessment of evolution, host adaptation and epidemic patterns ultimately helpful for adaptation of control strategies.
American Psychological Association (APA)
Nur, Islam& al-Anzi, Ibrahim Uqlah& Hanif, Atif& Ifan, Salih A.. 2021. Molecular adaptive evolution of SARS-COV-2 spike protein in Saudi Arabia. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3325-3332.
https://search.emarefa.net/detail/BIM-1410834
Modern Language Association (MLA)
al-Anzi, Ibrahim Uqlah…[et al.]. Molecular adaptive evolution of SARS-COV-2 spike protein in Saudi Arabia. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3325-3332.
https://search.emarefa.net/detail/BIM-1410834
American Medical Association (AMA)
Nur, Islam& al-Anzi, Ibrahim Uqlah& Hanif, Atif& Ifan, Salih A.. Molecular adaptive evolution of SARS-COV-2 spike protein in Saudi Arabia. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3325-3332.
https://search.emarefa.net/detail/BIM-1410834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3332
Record ID
BIM-1410834